Acceptor-donor-acceptor structured deep-red AIE photosensitizer: Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy

Li Huang; Deyan Qing; Shaojing Zhao; Xiaoli Wu; Ke Yang; Xiaojie Ren; Xiuli Zheng; Minhuan Lan; Jun Ye; Lintao Zeng; Guangle Niu

doi:10.1016/j.cej.2021.132638

Acceptor-donor-acceptor structured deep-red AIE photosensitizer: Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy

Li Huang, Deyan Qing, Shaojing Zhao, Xiaoli Wu, Ke Yang, Xiaojie Ren, Xiuli Zheng, Minhuan Lan^*, Jun Ye, Lintao Zeng, Guangle Niu

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51 引用（Scopus）

摘要

Photosensitizers (PSs) with aggregation-induced emission (AIE) feature show promising applications in fluorescence imaging-guided photodynamic therapy (PDT) in virtue of their enhanced fluorescence and phototoxicity in aggregate state. Seeking the ideal AIE luminogens (AIEgens) with good capability of generating reactive oxygen species is still urgent. Here we rationally synthesized an acceptor-donor-acceptor (A-D-A) structured AIEgen (BTZPP) and then prepared it into nanoparticles (NPs) through a simple re-precipitation procedure. The obtained BTZPP NPs show a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high ¹O₂ generation quantum yield of 72.3%. Moreover, these NPs can selectively target lysosomes in live cells and image mouse tumor with a high contrast and long-term tracking (up to 14 days) capability. The high-efficiency imaging-guided PDT against cancer cells and tumors is successfully demonstrated in vitro and in vivo.

源语言	英语
文章编号	132638
期刊	Chemical Engineering Journal
卷	430
DOI	https://doi.org/10.1016/j.cej.2021.132638
出版状态	已出版 - 15 2月 2022
已对外发布	是

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Huang, L., Qing, D., Zhao, S., Wu, X., Yang, K., Ren, X., Zheng, X., Lan, M., Ye, J., Zeng, L., & Niu, G. (2022). Acceptor-donor-acceptor structured deep-red AIE photosensitizer: Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy. Chemical Engineering Journal, 430, 文章 132638. https://doi.org/10.1016/j.cej.2021.132638

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title = "Acceptor-donor-acceptor structured deep-red AIE photosensitizer: Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy",

abstract = "Photosensitizers (PSs) with aggregation-induced emission (AIE) feature show promising applications in fluorescence imaging-guided photodynamic therapy (PDT) in virtue of their enhanced fluorescence and phototoxicity in aggregate state. Seeking the ideal AIE luminogens (AIEgens) with good capability of generating reactive oxygen species is still urgent. Here we rationally synthesized an acceptor-donor-acceptor (A-D-A) structured AIEgen (BTZPP) and then prepared it into nanoparticles (NPs) through a simple re-precipitation procedure. The obtained BTZPP NPs show a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high 1O2 generation quantum yield of 72.3%. Moreover, these NPs can selectively target lysosomes in live cells and image mouse tumor with a high contrast and long-term tracking (up to 14 days) capability. The high-efficiency imaging-guided PDT against cancer cells and tumors is successfully demonstrated in vitro and in vivo.",

keywords = "A-D-A structure, Aggregation induced emission, Long-term imaging, Lysosome targeting, Photosensitizer, ΔE",

author = "Li Huang and Deyan Qing and Shaojing Zhao and Xiaoli Wu and Ke Yang and Xiaojie Ren and Xiuli Zheng and Minhuan Lan and Jun Ye and Lintao Zeng and Guangle Niu",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2022",

month = feb,

day = "15",

doi = "10.1016/j.cej.2021.132638",

language = "English",

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T1 - Acceptor-donor-acceptor structured deep-red AIE photosensitizer

T2 - Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy

AU - Huang, Li

AU - Qing, Deyan

AU - Zhao, Shaojing

AU - Wu, Xiaoli

AU - Yang, Ke

AU - Ren, Xiaojie

AU - Zheng, Xiuli

AU - Lan, Minhuan

AU - Ye, Jun

AU - Zeng, Lintao

AU - Niu, Guangle

PY - 2022/2/15

Y1 - 2022/2/15

N2 - Photosensitizers (PSs) with aggregation-induced emission (AIE) feature show promising applications in fluorescence imaging-guided photodynamic therapy (PDT) in virtue of their enhanced fluorescence and phototoxicity in aggregate state. Seeking the ideal AIE luminogens (AIEgens) with good capability of generating reactive oxygen species is still urgent. Here we rationally synthesized an acceptor-donor-acceptor (A-D-A) structured AIEgen (BTZPP) and then prepared it into nanoparticles (NPs) through a simple re-precipitation procedure. The obtained BTZPP NPs show a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high 1O2 generation quantum yield of 72.3%. Moreover, these NPs can selectively target lysosomes in live cells and image mouse tumor with a high contrast and long-term tracking (up to 14 days) capability. The high-efficiency imaging-guided PDT against cancer cells and tumors is successfully demonstrated in vitro and in vivo.

AB - Photosensitizers (PSs) with aggregation-induced emission (AIE) feature show promising applications in fluorescence imaging-guided photodynamic therapy (PDT) in virtue of their enhanced fluorescence and phototoxicity in aggregate state. Seeking the ideal AIE luminogens (AIEgens) with good capability of generating reactive oxygen species is still urgent. Here we rationally synthesized an acceptor-donor-acceptor (A-D-A) structured AIEgen (BTZPP) and then prepared it into nanoparticles (NPs) through a simple re-precipitation procedure. The obtained BTZPP NPs show a deep-red emission peaked at 635 nm, a large Stokes shift of 195 nm, and a high 1O2 generation quantum yield of 72.3%. Moreover, these NPs can selectively target lysosomes in live cells and image mouse tumor with a high contrast and long-term tracking (up to 14 days) capability. The high-efficiency imaging-guided PDT against cancer cells and tumors is successfully demonstrated in vitro and in vivo.

KW - A-D-A structure

KW - Aggregation induced emission

KW - Long-term imaging

KW - Lysosome targeting

KW - Photosensitizer

KW - ΔE

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DO - 10.1016/j.cej.2021.132638

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JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

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Acceptor-donor-acceptor structured deep-red AIE photosensitizer: Lysosome-specific targeting, in vivo long-term imaging, and effective photodynamic therapy

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