A synthetic peptide derived from NK-lysin with activity against mycobacterium tuberculosis and its structure-function relationship

Gu Hao; Dai Rongji; Qiu Kui; Teng Zhongqiu; Wang Heyao

doi:10.1007/s10989-011-9268-6

A synthetic peptide derived from NK-lysin with activity against mycobacterium tuberculosis and its structure-function relationship

Gu Hao, Dai Rongji, Qiu Kui, Teng Zhongqiu, Wang Heyao^*

^*此作品的通讯作者

生命学院

科研成果: 期刊稿件 › 文章 › 同行评审

3 引用（Scopus）

摘要

As appearance of drug resistant and multidrug resistant strains of Mycobacterium tuberculosis, antibiotics were no longer the only way to inhibit M. tuberculosis. It was shown that the porcine peptide NK-lysin is active against various microbes by interacting with microbial membranes. The NK-lysin-derived peptide has been demonstrated to possess stronger effect. Under this motivation, we synthesized a short peptide (N22) derived from an active fragment of NK-lysin-an important antimycobaterial domain involving the loop and the α-helical structure. Furthermore, we studied its stability and biological activity in vitro. The results showed that it inhibited the growth of M. tuberculosis H37Rv and had a low toxicity to human erythrocyte.

源语言	英语
页（从-至）	301-306
页数	6
期刊	International Journal of Peptide Research and Therapeutics
卷	17
期	4
DOI	https://doi.org/10.1007/s10989-011-9268-6
出版状态	已出版 - 12月 2011

联合国可持续发展目标

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Hao, G., Rongji, D., Kui, Q., Zhongqiu, T., & Heyao, W. (2011). A synthetic peptide derived from NK-lysin with activity against mycobacterium tuberculosis and its structure-function relationship. International Journal of Peptide Research and Therapeutics, 17(4), 301-306. https://doi.org/10.1007/s10989-011-9268-6

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author = "Gu Hao and Dai Rongji and Qiu Kui and Teng Zhongqiu and Wang Heyao",

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AU - Hao, Gu

AU - Rongji, Dai

AU - Kui, Qiu

AU - Zhongqiu, Teng

AU - Heyao, Wang

PY - 2011/12

Y1 - 2011/12

N2 - As appearance of drug resistant and multidrug resistant strains of Mycobacterium tuberculosis, antibiotics were no longer the only way to inhibit M. tuberculosis. It was shown that the porcine peptide NK-lysin is active against various microbes by interacting with microbial membranes. The NK-lysin-derived peptide has been demonstrated to possess stronger effect. Under this motivation, we synthesized a short peptide (N22) derived from an active fragment of NK-lysin-an important antimycobaterial domain involving the loop and the α-helical structure. Furthermore, we studied its stability and biological activity in vitro. The results showed that it inhibited the growth of M. tuberculosis H37Rv and had a low toxicity to human erythrocyte.

AB - As appearance of drug resistant and multidrug resistant strains of Mycobacterium tuberculosis, antibiotics were no longer the only way to inhibit M. tuberculosis. It was shown that the porcine peptide NK-lysin is active against various microbes by interacting with microbial membranes. The NK-lysin-derived peptide has been demonstrated to possess stronger effect. Under this motivation, we synthesized a short peptide (N22) derived from an active fragment of NK-lysin-an important antimycobaterial domain involving the loop and the α-helical structure. Furthermore, we studied its stability and biological activity in vitro. The results showed that it inhibited the growth of M. tuberculosis H37Rv and had a low toxicity to human erythrocyte.

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A synthetic peptide derived from NK-lysin with activity against mycobacterium tuberculosis and its structure-function relationship

摘要

联合国可持续发展目标

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