摘要
Aiming at the two main shortcomings in Homology Modeling, we have designed and established a domain clustering database. Searching the database is a fundamental work for it. However, current alignment algorithms are mainly based on the sequences, ignoring the structure conservation in domain. This paper proposed a profile-based alignment which considers the structure information into the profile, based on the character of our domain database. We designed an experiment within the database. The results show that both the quality and sensitivity of our scheme are better than pure Smith-Waterman and sequence-based profile algorithms. We strongly believe that this work can help to improve the protein structure prediction.
| 源语言 | 英语 |
|---|---|
| 主期刊名 | Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 |
| 页 | 193-200 |
| 页数 | 8 |
| DOI | |
| 出版状态 | 已出版 - 2006 |
| 已对外发布 | 是 |
| 活动 | 3rd Computational Intelligence in Bioinformatics and Computational Biology Symposium, CIBCB - Toronto, ON, 加拿大 期限: 28 9月 2006 → 29 9月 2006 |
出版系列
| 姓名 | Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 |
|---|
会议
| 会议 | 3rd Computational Intelligence in Bioinformatics and Computational Biology Symposium, CIBCB |
|---|---|
| 国家/地区 | 加拿大 |
| 市 | Toronto, ON |
| 时期 | 28/09/06 → 29/09/06 |
指纹
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Xu, L., Zhang, F., & Liu, Z. (2006). A profile-based protein sequence alignment algorithm for a domain clustering database. 在 Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 (页码 193-200). 文章 4133172 (Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06). https://doi.org/10.1109/CIBCB.2006.330990