A potential biomarker of preclinical Alzheimer's disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments

Yan Yan, Ailikemu Aierken, Chunjian Wang, Da Song, Junjun Ni, Zhe Wang, Zhenzhen Quan*, Hong Qing

*此作品的通讯作者

科研成果: 期刊稿件文献综述同行评审

18 引用 (Scopus)

摘要

The olfactory dysfunction can signal and act as a potential biomarker of preclinical AD. However, the precise regulatory mechanism of olfactory function on the neural pathogenesis of AD is still unclear. The impairment of neural networks in olfaction system has been shown to be tightly associated with AD. As key brain regions of the olfactory system, the olfactory bulb (OB) and the piriform cortex (PCx) have a profound influence on the olfactory function. Therefore, this review will explore the mechanism of olfactory dysfunction in preclinical AD in the perspective of abnormal neural networks in the OB and PCx and their associated brain regions, especially from two aspects of aberrant oscillations and synaptic plasticity damages, which help better understand the underlying mechanism of olfactory neural network damages related to AD.

源语言英语
页(从-至)857-869
页数13
期刊Neuroscience and Biobehavioral Reviews
132
DOI
出版状态已出版 - 1月 2022

指纹

探究 'A potential biomarker of preclinical Alzheimer's disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments' 的科研主题。它们共同构成独一无二的指纹。

引用此

Yan, Y., Aierken, A., Wang, C., Song, D., Ni, J., Wang, Z., Quan, Z., & Qing, H. (2022). A potential biomarker of preclinical Alzheimer's disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments. Neuroscience and Biobehavioral Reviews, 132, 857-869. https://doi.org/10.1016/j.neubiorev.2021.11.009