A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

Deyao Zhao; Ge Yang; Qing Liu; Wenjing Liu; Yuhua Weng; Yi Zhao; Feng Qu; Lele Li; Yuanyu Huang

doi:10.1039/d0nr00301h

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

Deyao Zhao, Ge Yang, Qing Liu, Wenjing Liu, Yuhua Weng, Yi Zhao, Feng Qu, Lele Li, Yuanyu Huang^*

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

26 引用（Scopus）

摘要

A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

源语言	英语
页（从-至）	10939-10943
页数	5
期刊	Nanoscale
卷	12
期	20
DOI	https://doi.org/10.1039/d0nr00301h
出版状态	已出版 - 28 5月 2020

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abstract = "A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.",

author = "Deyao Zhao and Ge Yang and Qing Liu and Wenjing Liu and Yuhua Weng and Yi Zhao and Feng Qu and Lele Li and Yuanyu Huang",

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AU - Zhao, Deyao

AU - Yang, Ge

AU - Liu, Qing

AU - Liu, Wenjing

AU - Weng, Yuhua

AU - Zhao, Yi

AU - Qu, Feng

AU - Li, Lele

AU - Huang, Yuanyu

PY - 2020/5/28

Y1 - 2020/5/28

N2 - A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

AB - A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

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A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

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