TY - JOUR
T1 - A new crystal structure of clarithromycin
AU - Liang, Jian Hua
AU - Yao, Guo Wei
PY - 2008/1
Y1 - 2008/1
N2 - A new crystal structure of clarithromycin single acetonitrile solvate designated "Form III" was first determined by single crystal X-ray diffraction. The compound crystallized in the monoclinic system, P2 1 space group with a = 10.644(2) Å, b = 18.099(4) Å, c = 11.628(2) Å, α = γ = 90°, β = 95.38(3)°, V = 2230.1(8) Å3, Z = 2, D c = 1.175 g/cm3, μ = 0.087 mm-1, F(000) = 860, R 1 = 0.034, wR 2 = 0.062, S = 0.875, (Δ/σ)max = 0.001 for 2,709 observed reflections (I > 2σ (Ι)). Form III of clarithromycin, contrary to Form I, is more thermodynamically stable than Form II used currently on the market.
AB - A new crystal structure of clarithromycin single acetonitrile solvate designated "Form III" was first determined by single crystal X-ray diffraction. The compound crystallized in the monoclinic system, P2 1 space group with a = 10.644(2) Å, b = 18.099(4) Å, c = 11.628(2) Å, α = γ = 90°, β = 95.38(3)°, V = 2230.1(8) Å3, Z = 2, D c = 1.175 g/cm3, μ = 0.087 mm-1, F(000) = 860, R 1 = 0.034, wR 2 = 0.062, S = 0.875, (Δ/σ)max = 0.001 for 2,709 observed reflections (I > 2σ (Ι)). Form III of clarithromycin, contrary to Form I, is more thermodynamically stable than Form II used currently on the market.
KW - Clarithromycin
KW - Form III
KW - Regioselectivity
KW - Single crystal
UR - http://www.scopus.com/inward/record.url?scp=37449001554&partnerID=8YFLogxK
U2 - 10.1007/s10870-007-9287-5
DO - 10.1007/s10870-007-9287-5
M3 - Article
AN - SCOPUS:37449001554
SN - 1074-1542
VL - 38
SP - 61
EP - 64
JO - Journal of Chemical Crystallography
JF - Journal of Chemical Crystallography
IS - 1
ER -