A high-resolution interaction map of three transcriptional activation domains with a key coactivator from photo-cross-linking and multiplexed mass spectrometry

Chinmay Y. Majmudar, Bo Wang, Jenifer K. Lum, Kristina Hâkansson, Anna K. Mapp

科研成果: 期刊稿件文章同行评审

14 引用 (Scopus)

摘要

Binding with distinction: Photo-cross-linking followed by the complementary use of ESI and MALDI mass spectrometric techniques yielded the interaction sites of three prototypical amphipathic transcriptional activators (represented by different-colored helices in the picture) with the coactivator Med15. Investigation of the functional relevance of these sites in yeast revealed overlapping yet distinct binding patterns for the activators investigated.

源语言英语
页(从-至)7021-7024
页数4
期刊Angewandte Chemie - International Edition
48
38
DOI
出版状态已出版 - 7 9月 2009
已对外发布

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