A CoII complex for19F MRI-based detection of reactive oxygen species

Meng Yu; Da Xie; Khanh P. Phan; José S. Enriquez; Jeffrey J. Luci; Emily L. Que

doi:10.1039/c6cc08207f

A Co^II complex for¹⁹F MRI-based detection of reactive oxygen species

Meng Yu, Da Xie, Khanh P. Phan, José S. Enriquez, Jeffrey J. Luci, Emily L. Que^*

^*此作品的通讯作者

科研成果: 期刊稿件 › 文章 › 同行评审

46 引用（Scopus）

摘要

A fluorinated, air-stable cobalt(ii) complex serves as a turn-on¹⁹F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H₂O₂. Upon oxidation with H₂O₂, the complex converts from paramagnetic high spin Co^II to diamagnetic low spin Co^III resulting in a chemical shift change and enhancement in¹⁹F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na₂S₂O₄. The turn-on response is demonstrated by¹⁹F MRI, characterized by a ∼2-3 fold enhancement in signal.

源语言	英语
页（从-至）	13885-13888
页数	4
期刊	Chemical Communications
卷	52
期	96
DOI	https://doi.org/10.1039/c6cc08207f
出版状态	已出版 - 2016
已对外发布	是

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Yu, M., Xie, D., Phan, K. P., Enriquez, J. S., Luci, J. J., & Que, E. L. (2016). A Co^II complex for¹⁹F MRI-based detection of reactive oxygen species. Chemical Communications, 52(96), 13885-13888. https://doi.org/10.1039/c6cc08207f

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title = "A CoII complex for19F MRI-based detection of reactive oxygen species",

abstract = "A fluorinated, air-stable cobalt(ii) complex serves as a turn-on19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by19F MRI, characterized by a ∼2-3 fold enhancement in signal.",

author = "Meng Yu and Da Xie and Phan, {Khanh P.} and Enriquez, {Jos{\'e} S.} and Luci, {Jeffrey J.} and Que, {Emily L.}",

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year = "2016",

doi = "10.1039/c6cc08207f",

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AU - Yu, Meng

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AU - Luci, Jeffrey J.

AU - Que, Emily L.

PY - 2016

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AB - A fluorinated, air-stable cobalt(ii) complex serves as a turn-on19F magnetic resonance imaging (MRI) tracer for reactive oxygen species including H2O2. Upon oxidation with H2O2, the complex converts from paramagnetic high spin CoII to diamagnetic low spin CoIII resulting in a chemical shift change and enhancement in19F NMR signal. Further, the oxidation can be reversed in the presence of reductant Na2S2O4. The turn-on response is demonstrated by19F MRI, characterized by a ∼2-3 fold enhancement in signal.

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A CoII complex for19F MRI-based detection of reactive oxygen species

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A Co^II complex for¹⁹F MRI-based detection of reactive oxygen species