TY - JOUR
T1 - 11-Mercaptoundecanoic acid capped gold nanoclusters with unusual aggregation-enhanced emission for selective fluorometric hydrogen sulfide determination
AU - Lu, Fengniu
AU - Yang, Hongwei
AU - Tang, Ying
AU - Yu, Cheng Ju
AU - Wang, Guirong
AU - Yuan, Zhiqin
AU - Quan, Hengdao
N1 - Publisher Copyright:
© 2020, Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - In present study, we discovered unusual solvent-mediated aggregation-enhanced emission (AEE) character of 11-mercaptoundecanoic acid capped gold nanoclusters (MUA-Au NCs). When aggregated in aqueous media, the MUA-Au NCs showed strong emission, which was weakened by adding ethanol. Interestingly, the suppressed emission was selectively enhanced in the presence of hydrogen sulfide (H2S) because H2S was absorbed onto Au NCs through the strong sulfur-gold bonding affinity. The hydrolyzed H2S, namely, HS−, made the Au NCs negatively charged, which aggregated again due to decreased solubility. The H2S-mediated fluorescence enhancement can be further amplified by introducing a hydrophilic thiolate (glutathione, GSH) onto the surface of Au NCs (GSH/MUA-Au NCs), which enabled sensitive determination of H2S. Under the optimized condition, a detection limit of 35 nM was achieved. The determination was not interfered by other anions such as F−, Cl−, Br−, I−, OAc−, N3 −, NO3 −, HCO3 −, SCN−, SO3 2−, and SO4 2−. This excellent sensing performance allowed practical application of the GSH/MUA-Au NC-based sensing platform to accurate determination of H2S in human serum samples. [Figure not available: see fulltext.].
AB - In present study, we discovered unusual solvent-mediated aggregation-enhanced emission (AEE) character of 11-mercaptoundecanoic acid capped gold nanoclusters (MUA-Au NCs). When aggregated in aqueous media, the MUA-Au NCs showed strong emission, which was weakened by adding ethanol. Interestingly, the suppressed emission was selectively enhanced in the presence of hydrogen sulfide (H2S) because H2S was absorbed onto Au NCs through the strong sulfur-gold bonding affinity. The hydrolyzed H2S, namely, HS−, made the Au NCs negatively charged, which aggregated again due to decreased solubility. The H2S-mediated fluorescence enhancement can be further amplified by introducing a hydrophilic thiolate (glutathione, GSH) onto the surface of Au NCs (GSH/MUA-Au NCs), which enabled sensitive determination of H2S. Under the optimized condition, a detection limit of 35 nM was achieved. The determination was not interfered by other anions such as F−, Cl−, Br−, I−, OAc−, N3 −, NO3 −, HCO3 −, SCN−, SO3 2−, and SO4 2−. This excellent sensing performance allowed practical application of the GSH/MUA-Au NC-based sensing platform to accurate determination of H2S in human serum samples. [Figure not available: see fulltext.].
KW - Aggregation-enhanced emission
KW - Fluorometric detection
KW - Gold nanoclusters
KW - Human serum
KW - Hydrogen sulfide
UR - http://www.scopus.com/inward/record.url?scp=85081041281&partnerID=8YFLogxK
U2 - 10.1007/s00604-020-4159-1
DO - 10.1007/s00604-020-4159-1
M3 - Article
C2 - 32130538
AN - SCOPUS:85081041281
SN - 0026-3672
VL - 187
JO - Microchimica Acta
JF - Microchimica Acta
IS - 4
M1 - 200
ER -