TY - JOUR
T1 - 酶解骨粉对低钙大鼠的补钙功效研究
AU - Li, Yujuan
AU - Xiao, Nan
AU - Liu, Shan
AU - Liu, Feifei
AU - Sui, Yan
N1 - Publisher Copyright:
© 2022, Editorial Department of Transaction of Beijing Institute of Technology. All right reserved.
PY - 2022/1
Y1 - 2022/1
N2 - To investigate the effect of enzymatic hydrolyzed bone powder (EBP) on calcium supplement for low calcium rats. 6-week low calcium diet was used to establish a low calcium model. EBP (200, 400, 800 mg/kg) was orally administered to low calcium rats respectively for 4 weeks. The femur of rats was analyzed by HE staining.The mechanical index, dry weight, ash weight, and bone mineral density of the femur were measured. Femur calcium content, femur phosphorus content and the apparent absorption rate of calcium were determined. Results show that the bone trabecula is significantly decreased and the bone marrow cavity is remarkably enlarged in low calcium rats. After administration of EBP, the number of bone trabecula has increased and the area of bone marrow cavity has decreased. The bone mineral density of rats in high dose EBP can enhance by 14.1%. Besides, the content of calcium and phosphorus in the femur and the apparent absorption rate of calcium can increase significantly (p< 0.05). These findings suggest that EBP can promote calcium absorption, increase bone mineral density and bone calcium content in low calcium rats, being a potential calcium supplement.
AB - To investigate the effect of enzymatic hydrolyzed bone powder (EBP) on calcium supplement for low calcium rats. 6-week low calcium diet was used to establish a low calcium model. EBP (200, 400, 800 mg/kg) was orally administered to low calcium rats respectively for 4 weeks. The femur of rats was analyzed by HE staining.The mechanical index, dry weight, ash weight, and bone mineral density of the femur were measured. Femur calcium content, femur phosphorus content and the apparent absorption rate of calcium were determined. Results show that the bone trabecula is significantly decreased and the bone marrow cavity is remarkably enlarged in low calcium rats. After administration of EBP, the number of bone trabecula has increased and the area of bone marrow cavity has decreased. The bone mineral density of rats in high dose EBP can enhance by 14.1%. Besides, the content of calcium and phosphorus in the femur and the apparent absorption rate of calcium can increase significantly (p< 0.05). These findings suggest that EBP can promote calcium absorption, increase bone mineral density and bone calcium content in low calcium rats, being a potential calcium supplement.
KW - Bone mineral density
KW - Calcium supplement efficacy
KW - Calcium supplements
KW - Enzymatic hydrolyzed phosphate bone powder
UR - http://www.scopus.com/inward/record.url?scp=85122650399&partnerID=8YFLogxK
U2 - 10.15918/j.tbit1001-0645.2021.061
DO - 10.15918/j.tbit1001-0645.2021.061
M3 - 文章
AN - SCOPUS:85122650399
SN - 1001-0645
VL - 42
SP - 105
EP - 110
JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
IS - 1
ER -