基于纳米颗粒的化学发光技术在炎症及肿瘤诊疗中的应用

Optical technology plays a vital role in the field of biomedicine. It not only enables visualization of physiological or pathological processes at the cellular and subcellular dimensions in living subjects, but also improves the specificity and sensitivity of disease treatment. However, ordinary optical technology faces many challenges, including relatively low tissue penetration depth, low signal-to-noise ratio, and autofluorescence of the tissue. To overcome these problems, many researchers have gradually begun to focus on self-luminous technologies, including chemiluminescence, bioluminescence, and Cherenkov luminescence. Among them, chemiluminescence(CL) is a kind of light radiation phenomenon, which is produced by chemical substances in the process of chemical reactions. It has many advantages, including high sensitivity, no need for external light source excitation, breaking through the limit of tissue penetration depth, and improving the signal-to-noise ratio. These characteristics provide new ideas for the further development of optical imaging and treatment technology. However, due to the hydrophobicity of the chemiluminescent substance and other problems, its application in the field of biomedicine has been limited. To solve these problems, researchers have begun to combine nanotechnology with chemiluminescence technology, which not only expands the application range of chemiluminescence, but also further promotes the diagnosis and treatment of diseases. On this basis, the article first analyzes the molecular mechanism of chemiluminescence, secondly summarizes the application of chemiluminescence in the diagnosis and treatment of inflammation and tumor, and discusses the problems encountered in practical applications and the future development direction.