TY - JOUR
T1 - 基于交替方向乘子法(ADMM)直接重建心脏11C-acetate PET动力学参数图
AU - He, Shengji
AU - Liu, Shuai
AU - Zhang, Hui
AU - Huo, Li
AU - Shang, Fei
N1 - Publisher Copyright:
Copyright © 2022 by the Press of Chinese Journal of Medical Imaging and Technology.
PY - 2022/5/20
Y1 - 2022/5/20
N2 - Objective: To observe the value of direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on alternating direction method of multipliers (ADMM). Methods: Data of 11C-acetate PET images of 1 patient with early alcoholic cardiomyopathy was used to generate the ideal dynamic images, and the images were then projected to generate sinograms and added Poisson noise. PET images reconstruction were combined with the parameters calculation based on cardiac 11C-acetate single tissue compartment model, and the cardiac 11C-acetate PET kinetic parametric images were directly reconstructed with ADMM. The parametric images were indirectly reconstructed with ordered subsets expectation maximization (OSEM). The correlations of two reconstruction methods and reference standard were observed, and the value of direct reconstruction method was analyzed. Results: The indirect reconstruction took 23 min, while the direct reconstruction took 140 min. The average biases of K1, k2 and vl calculated with reference standard and indirect reconstruction was 2.97%, 1.61% and 10.19%, respectively, while between reference standard and direct reconstruction was 1.16%, 1.06% and 4.30%, respectively. K1, k2 and vl calculated with indirect or direct reconstruction were all strongly correlated with reference standard (all r>0.9, all P<0.001). Conclusion: Compared with indirect reconstruction, the accuracy of direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on ADMM was higher.
AB - Objective: To observe the value of direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on alternating direction method of multipliers (ADMM). Methods: Data of 11C-acetate PET images of 1 patient with early alcoholic cardiomyopathy was used to generate the ideal dynamic images, and the images were then projected to generate sinograms and added Poisson noise. PET images reconstruction were combined with the parameters calculation based on cardiac 11C-acetate single tissue compartment model, and the cardiac 11C-acetate PET kinetic parametric images were directly reconstructed with ADMM. The parametric images were indirectly reconstructed with ordered subsets expectation maximization (OSEM). The correlations of two reconstruction methods and reference standard were observed, and the value of direct reconstruction method was analyzed. Results: The indirect reconstruction took 23 min, while the direct reconstruction took 140 min. The average biases of K1, k2 and vl calculated with reference standard and indirect reconstruction was 2.97%, 1.61% and 10.19%, respectively, while between reference standard and direct reconstruction was 1.16%, 1.06% and 4.30%, respectively. K1, k2 and vl calculated with indirect or direct reconstruction were all strongly correlated with reference standard (all r>0.9, all P<0.001). Conclusion: Compared with indirect reconstruction, the accuracy of direct reconstruction of cardiac 11C-acetate PET kinetic parametric images based on ADMM was higher.
KW - Alternating direction method of multipliers
KW - Heart
KW - Nonlinear dynamics
KW - Positron-emission tomography
KW - Tracer
UR - http://www.scopus.com/inward/record.url?scp=85130764628&partnerID=8YFLogxK
U2 - 10.13929/j.issn.1003-3289.2022.05.029
DO - 10.13929/j.issn.1003-3289.2022.05.029
M3 - 文章
AN - SCOPUS:85130764628
SN - 1003-3289
VL - 38
SP - 758
EP - 763
JO - Chinese Journal of Medical Imaging Technology
JF - Chinese Journal of Medical Imaging Technology
IS - 5
ER -