@inproceedings{95ea4b5292b5456883e52e60126482cb,
title = "Weighted optimization of irradiance for photodynamic therapy of port wine stains",
abstract = "Planning of irradiance distribution (PID) is one of the foremost factors for on-demand treatment of port wine stains (PWS) with photodynamic therapy (PDT). A weighted optimization method for PID was proposed according to the grading of PWS with a three dimensional digital illumination instrument. Firstly, the point clouds of lesions were filtered to remove the error or redundant points, the triangulation was carried out and the lesion was divided into small triangular patches. Secondly, the parameters such as area, normal vector and orthocenter for optimization of each triangular patch were calculated, and the weighted coefficients were determined by the erythema indexes and areas of patches. Then, the optimization initial point was calculated based on the normal vectors and orthocenters to optimize the light direction. In the end, the irradiation can be optimized according to cosine values of irradiance angles and weighted coefficients. Comparing the irradiance distribution before and after optimization, the proposed weighted optimization method can make the irradiance distribution match better with the characteristics of lesions, and has the potential to improve the therapeutic efficacy.",
keywords = "irradiance planning, lesions grading, photodynamic therapy, weighted optimization method",
author = "Linhuan He and Ya Zhou and Xiaoming Hu",
note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Optics in Health Care and Biomedical Optics VII ; Conference date: 12-10-2016 Through 14-10-2016",
year = "2016",
doi = "10.1117/12.2246156",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Yuguo Tang and Xingde Li and Ying Gu and Dan Zhu and Qingming Luo",
booktitle = "Optics in Health Care and Biomedical Optics VII",
address = "United States",
}