Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks

Jiangjiang Zhang; Ying Li; Fengli Chai; Qizhen Li; Dou Wang; Liping Liu; Ben Zhong Tang; Xingyu Jiang

doi:10.1126/sciadv.abo1874

Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks

Jiangjiang Zhang, Ying Li, Fengli Chai, Qizhen Li, Dou Wang, Liping Liu^*, Ben Zhong Tang^*, Xingyu Jiang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors. MAFs process a unique luminescent mechanism of structural rigidity-enhanced emission to achieve a high quantum yield (~99.9%). We optimized the MAFs to show 10²- to 10³-fold enhanced sensitivity for a hydrogel-based POC digital sensor and lateral flow immunoassays (LFIA). MAFs have a high affinity to directly absorb proteins, which can label antibodies for immunoassays. MAFs-based LFIA with enhanced sensitivity shows robust serum detection for POC clinical diagnosis.

Original language	English
Article number	eabo1874
Journal	Science advances
Volume	8
Issue number	30
DOIs	https://doi.org/10.1126/sciadv.abo1874
Publication status	Published - 29 Jul 2022
Externally published	Yes

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Zhang, J., Li, Y., Chai, F., Li, Q., Wang, D., Liu, L., Tang, B. Z., & Jiang, X. (2022). Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks. Science advances, 8(30), Article eabo1874. https://doi.org/10.1126/sciadv.abo1874

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abstract = "Point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors. MAFs process a unique luminescent mechanism of structural rigidity-enhanced emission to achieve a high quantum yield (~99.9%). We optimized the MAFs to show 102- to 103-fold enhanced sensitivity for a hydrogel-based POC digital sensor and lateral flow immunoassays (LFIA). MAFs have a high affinity to directly absorb proteins, which can label antibodies for immunoassays. MAFs-based LFIA with enhanced sensitivity shows robust serum detection for POC clinical diagnosis.",

author = "Jiangjiang Zhang and Ying Li and Fengli Chai and Qizhen Li and Dou Wang and Liping Liu and Tang, {Ben Zhong} and Xingyu Jiang",

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AU - Li, Ying

AU - Chai, Fengli

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AU - Wang, Dou

AU - Liu, Liping

AU - Tang, Ben Zhong

AU - Jiang, Xingyu

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Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks

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