Topological reorganization after partial auditory deprivation—a structural connectivity study in single-sided deafness

Xuesong Li, Yufei Qiao, Hang Shen, Zhendong Niu, Yingying Shang*, Hua Guo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Growing evidence shows that partial auditory deprivation leads to extensive neural functional plasticity, which occurs not only in the auditory cortex but also in other sensory regions and cognitive areas. However, studies in structural topological properties are still limited, especially those investigating the relationship between structural connectome alterations and auditory abilities. To clarify this, we investigated white matter structural connectivity changes and the relationship between connection strength and hearing abilities in individuals with long-term single-sided deafness (SSD), a common form of partial hearing deprivation, using diffusion tensor imaging and network-based analysis. The results showed globally improved connection efficiency, locally weakened visual networks, and strengthened fronto-parietal sub-networks in SSD compared to normal hearing controls. Furthermore, a strong positive correlation between hearing abilities (including speech recognition in noise and sound localization) and connection strength, mainly in the fronto-parietal areas, was found in SSD. Our study reveals alteration of the structural network connections in SSD, especially in cognitive related networks, which showed close correlation with hearing abilities. Our findings provide new insights into topological white matter reorganization of the brain after partial sensory deprivation.

Original languageEnglish
Pages (from-to)75-83
Number of pages9
JournalHearing Research
Volume380
DOIs
Publication statusPublished - 1 Sept 2019

Keywords

  • Auditory deprivation
  • DTI
  • Reorganization
  • Single-sided deafness
  • Structural connectivity

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