The Roles of Solute Carriers in Auditory Function

Fuping Qian, Xiaoge Jiang, Renjie Chai*, Dong Liu*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. SLCs also play important roles in hearing. It has been found that mutations in some SLC members are associated with hearing loss. In this review, we summarize SLC family genes related with hearing dysfunction to reveal the vital roles of these transporters in auditory function. This summary could help us understand the auditory physiology and the mechanisms of hearing loss and further guide future studies of deafness gene identification.

Original languageEnglish
Article number823049
JournalFrontiers in Genetics
Volume13
DOIs
Publication statusPublished - 26 Jan 2022
Externally publishedYes

Keywords

  • SLC
  • deafness gene
  • hereditary hearing loss
  • solute carrier
  • transporter

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Qian, F., Jiang, X., Chai, R., & Liu, D. (2022). The Roles of Solute Carriers in Auditory Function. Frontiers in Genetics, 13, Article 823049. https://doi.org/10.3389/fgene.2022.823049