The roles of Rab protein family in neurological diseases

An Ping Wu; Hong Qing; Zhen Zhen Quan

doi:10.16288/j.yczz.20-318

The roles of Rab protein family in neurological diseases

An Ping Wu, Hong Qing, Zhen Zhen Quan

School of Life Science

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

细胞内膜囊泡运输是一个复杂的通路网络,Rab GTPases是膜囊泡运输的主要调节剂,通常被认为是细胞内吞和分泌系统中各种细胞器和囊泡的特异性标记和识别物。与Rab蛋白相关的轴突运输、内体运输发生障碍是造成神经退行性疾病的重要原因之一。本文主要介绍了Rab蛋白在多种神经退行性疾病病理机制中的作用机理与调控机制,同时讨论了线粒体和胶质细胞功能异常与Rab蛋白之间的关联。深入探究Rab蛋白的作用机制对人类神经性疾病的早期诊断和治疗具有潜在的指导意义。.

Original language	English
Pages (from-to)	16-29
Number of pages	14
Journal	Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji
Volume	43
Issue number	1
DOIs	https://doi.org/10.16288/j.yczz.20-318
Publication status	Published - 20 Jan 2021

Keywords

Rab proteins
astrocytes
membrane trafficking
mitochondria
neurological diseases

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10.16288/j.yczz.20-318

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abstract = "细胞内膜囊泡运输是一个复杂的通路网络,Rab GTPases是膜囊泡运输的主要调节剂,通常被认为是细胞内吞和分泌系统中各种细胞器和囊泡的特异性标记和识别物。与Rab蛋白相关的轴突运输、内体运输发生障碍是造成神经退行性疾病的重要原因之一。本文主要介绍了Rab蛋白在多种神经退行性疾病病理机制中的作用机理与调控机制,同时讨论了线粒体和胶质细胞功能异常与Rab蛋白之间的关联。深入探究Rab蛋白的作用机制对人类神经性疾病的早期诊断和治疗具有潜在的指导意义。.",

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The roles of Rab protein family in neurological diseases

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