The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Da Song; Deheng Wang; Qinghu Yang; Tianyi Yan; Zhe Wang; Yan Yan; Juan Zhao; Zhen Xie; Yuchen Liu; Zunji Ke; Talal Jamil Qazi; Yanhui Li; Yili Wu; Qing Shi; Yiran Lang; Heao Zhang; Tao Huang; Chunjian Wang; Zhenzhen Quan; Hong Qing

doi:10.1038/s41467-020-16698-4

The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Da Song, Deheng Wang, Qinghu Yang, Tianyi Yan, Zhe Wang, Yan Yan, Juan Zhao, Zhen Xie, Yuchen Liu, Zunji Ke, Talal Jamil Qazi, Yanhui Li, Yili Wu, Qing Shi, Yiran Lang, Heao Zhang, Tao Huang, Chunjian Wang, Zhenzhen Quan^*, Hong Qing

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MS^PV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.

Original language	English
Article number	2901
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-16698-4
Publication status	Published - 1 Dec 2020

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Song, D., Wang, D., Yang, Q., Yan, T., Wang, Z., Yan, Y., Zhao, J., Xie, Z., Liu, Y., Ke, Z., Qazi, T. J., Li, Y., Wu, Y., Shi, Q., Lang, Y., Zhang, H., Huang, T., Wang, C., Quan, Z., & Qing, H. (2020). The lateralization of left hippocampal CA3 during the retrieval of spatial working memory. Nature Communications, 11(1), Article 2901. https://doi.org/10.1038/s41467-020-16698-4

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title = "The lateralization of left hippocampal CA3 during the retrieval of spatial working memory",

abstract = "The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.",

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AU - Zhao, Juan

AU - Xie, Zhen

AU - Liu, Yuchen

AU - Ke, Zunji

AU - Qazi, Talal Jamil

AU - Li, Yanhui

AU - Wu, Yili

AU - Shi, Qing

AU - Lang, Yiran

AU - Zhang, Heao

AU - Huang, Tao

AU - Wang, Chunjian

AU - Quan, Zhenzhen

AU - Qing, Hong

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N2 - The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.

AB - The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression of pyramidal neurons in LCA3 disrupts SWM only in the choice phase. Furthermore, we discover that parvalbumin (PV) neurons, rather than cholinergic neurons in the medial septum (DB were cholinergic neurons), can project directly to unilateral CA3. Selective suppression of PV neurons in the MS projecting to LCA3 impairs SWM. The findings suggest that MSPV-LCA3 projection plays a crucial role in manipulating the lateralization of LCA3 in the retrieval of SWM.

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The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

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