The evaluation and planning of light dose in photodynamic therapy for port wine stains

Feng Juan Zhang, Xiao Ming Hu*, Qi Shen Zhang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

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Abstract

Photodynamic therapy (PDT) is one of the best available treatment for dermatology, especially for port wine stains (PWS), in which the efficacy is associated with the light dose, the photosensitizer concentration, the oxygen concentration and so on. Accurate control of the light dose will help doctors develop more effective treatment protocols, and reduce the treatment cost. Considering the characters of PWS, a binocular vision system composed of a camera, a digital projector and a computing unit is designed. An accurate 3D modeling of patients was achieved using a gray coding structured light, and then the lesions were segmented based on HSV space. Subsequently, each 3D point is fit on the surface by a nearest neighbor algorithm and the surface normal can be obtained. Three dimensional localization of lesion provide digital objective basis for automatic control of light device. The irradiance on the surface at a given angle can be assessed, and the optimum angle for the treatment can be solved and optimized by the doctor to improve irradiation areas.

Original languageEnglish
Title of host publicationOptics in Health Care and Biomedical Optics VI
EditorsQingming Luo, Yuguo Tang, Xingde Li, Ying Gu
PublisherSPIE
ISBN (Electronic)9781628413410
DOIs
Publication statusPublished - 2014
EventOptics in Health Care and Biomedical Optics VI - Beijing, China
Duration: 9 Oct 201411 Oct 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9268
ISSN (Print)1605-7422

Conference

ConferenceOptics in Health Care and Biomedical Optics VI
Country/TerritoryChina
CityBeijing
Period9/10/1411/10/14

Keywords

  • 3D reconstruction
  • Light dose
  • Photodynamic therapy
  • Port wine stains

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Zhang, F. J., Hu, X. M., & Zhang, Q. S. (2014). The evaluation and planning of light dose in photodynamic therapy for port wine stains. In Q. Luo, Y. Tang, X. Li, & Y. Gu (Eds.), Optics in Health Care and Biomedical Optics VI Article 926806 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9268). SPIE. https://doi.org/10.1117/12.2071307