The biological effects of radiation-induced liver damage and its natural protective medicine

Tianmei Li, Yanlu Cao, Bo Li*, Rongji Dai

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)

Abstract

The biological damage caused by the environmental factors such as radiation and its control methods are one of the frontiers of life science research that has received widespread attention. Ionizing radiation can directly interact with target molecules (such as DNA, proteins and lipids) or decomposed by radiation from water, leading to changes in oxidative events and biological activities in cells. Liver is a radiation-sensitive organ, and its radiosensitivity is second only to bone marrow, lymph, gastrointestinal tissue, gonads, embryos and kidneys. In addition, as a key organ of mammals, liver performs a series of functions, including the production of bile, the metabolism of nutrients, the elimination of waste, the storage of glycogen, and the synthesis of proteins. Therefore, liver is prone to various pathophysiological changes. In this review, the effects of radiation on liver injury, its pathogenesis, bystander effect and the natural traditional Chinese medicine to protect the radiation induced liver damage are discussed.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalProgress in Biophysics and Molecular Biology
Volume167
DOIs
Publication statusPublished - Dec 2021

Keywords

  • Liver injury
  • Liver-brain axis
  • Natural protective medicine
  • Radiation

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Li, T., Cao, Y., Li, B., & Dai, R. (2021). The biological effects of radiation-induced liver damage and its natural protective medicine. Progress in Biophysics and Molecular Biology, 167, 87-95. https://doi.org/10.1016/j.pbiomolbio.2021.06.012