Synthesis of [18O2]-curcumin

Xiurui Shen; Xiaomei Yang; Ying Zhu; Xihuan Liu; Hongliang Wen

doi:10.1002/jlcr.3238

Synthesis of [¹⁸O₂]-curcumin

Xiurui Shen, Xiaomei Yang, Ying Zhu, Xihuan Liu, Hongliang Wen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [¹⁸O₂]-curcumin. [¹⁸O₂]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.

Original language	English
Pages (from-to)	658-659
Number of pages	2
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	57
Issue number	11
DOIs	https://doi.org/10.1002/jlcr.3238
Publication status	Published - 29 Sept 2014

Keywords

Curcumin
Hydroxylation
O-labelling
Synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/jlcr.3238

Cite this

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abstract = "Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [18O2]-curcumin. [18O2]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.",

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AU - Liu, Xihuan

AU - Wen, Hongliang

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KW - O-labelling

KW - Synthesis

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