Synthesis, antitumor and apoptosis inducing activities of novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates

Changgen Feng; Qiang Gan; Xia Liu; Hongyou He

doi:10.1002/cjoc.201100744

Synthesis, antitumor and apoptosis inducing activities of novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates

Changgen Feng^*, Qiang Gan, Xia Liu, Hongyou He

^*Corresponding author for this work

School of Mechatronical Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates, K ₉(C ₄H ₄FN ₂O ₂) ₂Sm(PW ₁₁O ₃₉) ₂· 11H ₂O (FSmPW) and K ₉H(C ₄H ₄FN ₂O ₂)Eu(PW ₁₁O ₃₉) ₂· 11H ₂O (FEuPW) were synthesized and characterized by element analysis, ICP, FT-IR, ¹H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT-IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C ₄H ₄FN ₂O ₂H ₂PW ₁₂O ₄₀· 8H ₂O, and the IC ₅₀ values of FSmPW and FEuPW are 4.20, 3.49 μmol·L ^-1 against HeLa cells and 4.62, 7.19 μmol·L ^-1 against HepG-2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxicity of polyoxometalates.

Original language	English
Pages (from-to)	1589-1593
Number of pages	5
Journal	Chinese Journal of Chemistry
Volume	30
Issue number	7
DOIs	https://doi.org/10.1002/cjoc.201100744
Publication status	Published - Jul 2012

Keywords

HeLa
HepG-2
antitumor
apoptosis
polyoxometalates
rare earth

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title = "Synthesis, antitumor and apoptosis inducing activities of novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates",

abstract = "Two novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates, K 9(C 4H 4FN 2O 2) 2Sm(PW 11O 39) 2· 11H 2O (FSmPW) and K 9H(C 4H 4FN 2O 2)Eu(PW 11O 39) 2· 11H 2O (FEuPW) were synthesized and characterized by element analysis, ICP, FT-IR, 1H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT-IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C 4H 4FN 2O 2H 2PW 12O 40· 8H 2O, and the IC 50 values of FSmPW and FEuPW are 4.20, 3.49 μmol·L -1 against HeLa cells and 4.62, 7.19 μmol·L -1 against HepG-2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxicity of polyoxometalates.",

keywords = "HeLa, HepG-2, antitumor, apoptosis, polyoxometalates, rare earth",

author = "Changgen Feng and Qiang Gan and Xia Liu and Hongyou He",

year = "2012",

month = jul,

doi = "10.1002/cjoc.201100744",

language = "English",

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pages = "1589--1593",

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TY - JOUR

T1 - Synthesis, antitumor and apoptosis inducing activities of novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates

AU - Feng, Changgen

AU - Gan, Qiang

AU - Liu, Xia

AU - He, Hongyou

PY - 2012/7

Y1 - 2012/7

N2 - Two novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates, K 9(C 4H 4FN 2O 2) 2Sm(PW 11O 39) 2· 11H 2O (FSmPW) and K 9H(C 4H 4FN 2O 2)Eu(PW 11O 39) 2· 11H 2O (FEuPW) were synthesized and characterized by element analysis, ICP, FT-IR, 1H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT-IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C 4H 4FN 2O 2H 2PW 12O 40· 8H 2O, and the IC 50 values of FSmPW and FEuPW are 4.20, 3.49 μmol·L -1 against HeLa cells and 4.62, 7.19 μmol·L -1 against HepG-2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxicity of polyoxometalates.

AB - Two novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates, K 9(C 4H 4FN 2O 2) 2Sm(PW 11O 39) 2· 11H 2O (FSmPW) and K 9H(C 4H 4FN 2O 2)Eu(PW 11O 39) 2· 11H 2O (FEuPW) were synthesized and characterized by element analysis, ICP, FT-IR, 1H NMR and XRD analysis. Thermal stability analysis was performed by TG and FT-IR. The results of MTT assay show that FSmPW and FEuPW have higher cytotoxicity than known compound C 4H 4FN 2O 2H 2PW 12O 40· 8H 2O, and the IC 50 values of FSmPW and FEuPW are 4.20, 3.49 μmol·L -1 against HeLa cells and 4.62, 7.19 μmol·L -1 against HepG-2 cells. Apoptosis analysis reveals the apoptosis inducing activity of the two compounds, which may play an important role in the cytotoxicity of polyoxometalates.

KW - HeLa

KW - HepG-2

KW - antitumor

KW - apoptosis

KW - polyoxometalates

KW - rare earth

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U2 - 10.1002/cjoc.201100744

DO - 10.1002/cjoc.201100744

M3 - Article

AN - SCOPUS:84864141261

SN - 1001-604X

VL - 30

SP - 1589

EP - 1593

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 7

ER -

Synthesis, antitumor and apoptosis inducing activities of novel 5-fluorouracil derivatives of rare earth (Sm, Eu) substituted polyoxometalates

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