TY - JOUR
T1 - Synthesis and characterization of carboxymethyl chitosan/epoxidized soybean oil based conjugate catalyed by UV light, and its application as drug carrier for fusarium wilt
AU - Zhou, Chuang
AU - Zhang, Li
AU - Yang, Ziming
AU - Pan, Qingyan
AU - He, Zuyu
AU - Wang, Chao
AU - Liu, Yunhao
AU - Song, Shuhui
AU - Yang, Zhuohong
AU - Chen, Yu
AU - Li, Puwang
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - In this paper, a cationic photoinitiator (TAS) was used as a catalyst for the ring opening reaction of carboxymethyl chitosan (CMCS) and epoxidized soybean oil (ESO) under UV light to prepare CMCS-g-ESO conjugate, and the structure of the product was characterized by FT-IR, 1H NMR and GPC. Then, the spinosad-loaded microcapsules (SSD@CMCS-g-ESO) were prepared by ultrasonic self-assembly method. The results showed that TAS could catalyze the ring opening reaction of CMCS and ESO under UV-irradiation and the optimum reaction time was 1 h, with the molecular weight of 15,745. The average particle size of SSD@CMCS-g-ESO was about 2.16 μm, and the encapsulation efficiency (EE) and drug loading content (LC) of SSD@CMCS-g-ESO were 85.39 ± 2.05% and 20.17 ± 1.84%, respectively. In vitro release revealed that SSD@CMCS-g-ESO exhibited sustained-release and pH-responsive property, and the accumulative release in the buffer solution of pH = 6.5 and 7.4 was higher than in pH = 9.0. Furthermore, SSD@CMCS-g-ESO had a good antifungal properties against Fusarium oxysporum f. sp. cubense (Foc) compared with the unencapsulated SSD at the same drug dose. This work indicated that photo-chemical reactions could be used to prepare bio-based carrier materials to construct drugs delivery system for targeted treatment of fusarium wilt.
AB - In this paper, a cationic photoinitiator (TAS) was used as a catalyst for the ring opening reaction of carboxymethyl chitosan (CMCS) and epoxidized soybean oil (ESO) under UV light to prepare CMCS-g-ESO conjugate, and the structure of the product was characterized by FT-IR, 1H NMR and GPC. Then, the spinosad-loaded microcapsules (SSD@CMCS-g-ESO) were prepared by ultrasonic self-assembly method. The results showed that TAS could catalyze the ring opening reaction of CMCS and ESO under UV-irradiation and the optimum reaction time was 1 h, with the molecular weight of 15,745. The average particle size of SSD@CMCS-g-ESO was about 2.16 μm, and the encapsulation efficiency (EE) and drug loading content (LC) of SSD@CMCS-g-ESO were 85.39 ± 2.05% and 20.17 ± 1.84%, respectively. In vitro release revealed that SSD@CMCS-g-ESO exhibited sustained-release and pH-responsive property, and the accumulative release in the buffer solution of pH = 6.5 and 7.4 was higher than in pH = 9.0. Furthermore, SSD@CMCS-g-ESO had a good antifungal properties against Fusarium oxysporum f. sp. cubense (Foc) compared with the unencapsulated SSD at the same drug dose. This work indicated that photo-chemical reactions could be used to prepare bio-based carrier materials to construct drugs delivery system for targeted treatment of fusarium wilt.
KW - Antifungal
KW - Microcapsules
KW - Photo-chemical reactions
UR - http://www.scopus.com/inward/record.url?scp=85130191109&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2022.05.118
DO - 10.1016/j.ijbiomac.2022.05.118
M3 - Article
C2 - 35598563
AN - SCOPUS:85130191109
SN - 0141-8130
VL - 212
SP - 11
EP - 19
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -