Synthesis and characterization of biodegradable polyurethane based on poly(ε-caprolactone) and L-lysine ethyl ester diisocyanate

Jian Han, Bing Chen, Lin Ye, Ai Ying Zhang, Jian Zhang, Zeng Guo Feng

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

A biocompatible diisocyanate, lysine ethyl ester diisocyanate, was prepared. Afterwards, biodegradable polyurethane (PU) was synthesized by the stepgrowth polymerization of this diisocyanate with hydroxyl terminated poly(ε-caprolactone) in the presence of 1,4-butanediol as a chain-extender. The resulting PU was characterized by GPC, IR and DSC measurements. Its mechanical strength was found to increase with increasing the hard segment content. The PU microfiber meshes with high porosity were obtained by solution electrospinning technique. Their degradation behavior in the PBS and enzymatic solution was also investigated.

Original languageEnglish
Pages (from-to)25-32
Number of pages8
JournalFrontiers of Materials Science in China
Volume3
Issue number1
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Biodegradability
  • L-lysine ethyl ester diisocyanate
  • Poly(ε-caprolactone)
  • Polyurethane
  • Solution electrospinning

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