Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid

Yi Liu; Yulin Deng; Rong Zheng; Peilong Zhang; Hui Zhai; Changjin Zhu

doi:10.1248/cpb.54.832

Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid

Yi Liu, Yulin Deng, Rong Zheng, Peilong Zhang, Hui Zhai, Changjin Zhu^*

^*Corresponding author for this work

School of Medical and Technology

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

In order to improve the cell penetration of polyamide and its movement toward nucleic DNA we synthesized a conjugate of polyamide and phospholipid, which showed a significantly reducecd cytotoxicity and effective apoptosis when comparing with the native polyamide.

Original language	English
Pages (from-to)	832-835
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	54
Issue number	6
DOIs	https://doi.org/10.1248/cpb.54.832
Publication status	Published - Jun 2006

Keywords

Apoptosis
Cytotoxicity
Phospholipid conjugate
Polyamide

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10.1248/cpb.54.832

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Liu, Y., Deng, Y., Zheng, R., Zhang, P., Zhai, H., & Zhu, C. (2006). Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid. Chemical and Pharmaceutical Bulletin, 54(6), 832-835. https://doi.org/10.1248/cpb.54.832

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title = "Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid",

abstract = "In order to improve the cell penetration of polyamide and its movement toward nucleic DNA we synthesized a conjugate of polyamide and phospholipid, which showed a significantly reducecd cytotoxicity and effective apoptosis when comparing with the native polyamide.",

keywords = "Apoptosis, Cytotoxicity, Phospholipid conjugate, Polyamide",

author = "Yi Liu and Yulin Deng and Rong Zheng and Peilong Zhang and Hui Zhai and Changjin Zhu",

year = "2006",

month = jun,

doi = "10.1248/cpb.54.832",

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T1 - Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid

AU - Liu, Yi

AU - Deng, Yulin

AU - Zheng, Rong

AU - Zhang, Peilong

AU - Zhai, Hui

AU - Zhu, Changjin

PY - 2006/6

Y1 - 2006/6

N2 - In order to improve the cell penetration of polyamide and its movement toward nucleic DNA we synthesized a conjugate of polyamide and phospholipid, which showed a significantly reducecd cytotoxicity and effective apoptosis when comparing with the native polyamide.

AB - In order to improve the cell penetration of polyamide and its movement toward nucleic DNA we synthesized a conjugate of polyamide and phospholipid, which showed a significantly reducecd cytotoxicity and effective apoptosis when comparing with the native polyamide.

KW - Apoptosis

KW - Cytotoxicity

KW - Phospholipid conjugate

KW - Polyamide

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U2 - 10.1248/cpb.54.832

DO - 10.1248/cpb.54.832

M3 - Article

C2 - 16755053

AN - SCOPUS:33744775939

SN - 0009-2363

VL - 54

SP - 832

EP - 835

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 6

ER -

Synthesis and cellular effect of a novel conjugate of polyamide and phospholipid

Abstract

Keywords

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