Synthesis and biological activity of titanocene carbohydrate

Zhan Zhu; Bing Nan Guo; Ya Li Wang; Jing Jing Dou; Shi Zhuo Xu

Synthesis and biological activity of titanocene carbohydrate

Zhan Zhu^*, Bing Nan Guo, Ya Li Wang, Jing Jing Dou, Shi Zhuo Xu

^*Corresponding author for this work

School of Foreign Languages

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp ₂TiCl ₂. They were C ₁₂H ₂₁O ₁₂· C ₁₀H ₁₀TiCl, C ₁₄H ₂₀NO ₁₁· C ₁₀H ₁₀TiCl·8H ₂O, C ₁₂H ₂₁O ₁₂· C ₁₄H ₂₀NO ₁₁· C ₁₀H ₁₀Ti·26H ₂O and C ₁₄H ₂₄NO ₁₃ C ₁₀H ₁₀TiCl. All compounds were characterizated by IR, ¹H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.

Original language	English
Pages (from-to)	531-534
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	32
Issue number	5
Publication status	Published - May 2012

Keywords

Cervical cancer
Hepatic targeting
Liver cancer
Titanocene carbohydrate
Titanocene dichloride

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Synthesis and biological activity of titanocene carbohydrate",

abstract = "Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp 2TiCl 2. They were C 12H 21O 12· C 10H 10TiCl, C 14H 20NO 11· C 10H 10TiCl·8H 2O, C 12H 21O 12· C 14H 20NO 11· C 10H 10Ti·26H 2O and C 14H 24NO 13 C 10H 10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.",

keywords = "Cervical cancer, Hepatic targeting, Liver cancer, Titanocene carbohydrate, Titanocene dichloride",

author = "Zhan Zhu and Guo, {Bing Nan} and Wang, {Ya Li} and Dou, {Jing Jing} and Xu, {Shi Zhuo}",

year = "2012",

month = may,

language = "English",

volume = "32",

pages = "531--534",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

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}

TY - JOUR

T1 - Synthesis and biological activity of titanocene carbohydrate

AU - Zhu, Zhan

AU - Guo, Bing Nan

AU - Wang, Ya Li

AU - Dou, Jing Jing

AU - Xu, Shi Zhuo

PY - 2012/5

Y1 - 2012/5

N2 - Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp 2TiCl 2. They were C 12H 21O 12· C 10H 10TiCl, C 14H 20NO 11· C 10H 10TiCl·8H 2O, C 12H 21O 12· C 14H 20NO 11· C 10H 10Ti·26H 2O and C 14H 24NO 13 C 10H 10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.

AB - Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp 2TiCl 2. They were C 12H 21O 12· C 10H 10TiCl, C 14H 20NO 11· C 10H 10TiCl·8H 2O, C 12H 21O 12· C 14H 20NO 11· C 10H 10Ti·26H 2O and C 14H 24NO 13 C 10H 10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited.

KW - Cervical cancer

KW - Hepatic targeting

KW - Liver cancer

KW - Titanocene carbohydrate

KW - Titanocene dichloride

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M3 - Article

AN - SCOPUS:84863748885

SN - 1001-0645

VL - 32

SP - 531

EP - 534

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 5

ER -

Synthesis and biological activity of titanocene carbohydrate

Abstract

Keywords

UN SDGs

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