Synthesis and antitumor activity of novel 2′,3′-diethanethio- 2′,3′,5′-trideoxy-5′-triazolonucleoside analogues

Jin Lan Yu; Qin Pei Wu; Qing Shan Zhang; Xiao Dong Xi; Ning Ning Liu; Yun Zheng Li; Yan Hong Liu; Hong Quan Yin

doi:10.1016/j.ejmech.2010.03.038

Synthesis and antitumor activity of novel 2′,3′-diethanethio- 2′,3′,5′-trideoxy-5′-triazolonucleoside analogues

Jin Lan Yu, Qin Pei Wu^*, Qing Shan Zhang, Xiao Dong Xi, Ning Ning Liu, Yun Zheng Li, Yan Hong Liu, Hong Quan Yin

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A series of novel 2′,3′-diethanethio-2′,3′, 5′-trideoxy-5′-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.

Original language	English
Pages (from-to)	3219-3222
Number of pages	4
Journal	European Journal of Medicinal Chemistry
Volume	45
Issue number	7
DOIs	https://doi.org/10.1016/j.ejmech.2010.03.038
Publication status	Published - Jul 2010

Keywords

Antitumor
Cancer therapy
Nucleoside
Targeted therapy
Triazole

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejmech.2010.03.038

Cite this

@article{2b8a7e628df5404588e0ff40523b9cf9,

title = "Synthesis and antitumor activity of novel 2′,3′-diethanethio- 2′,3′,5′-trideoxy-5′-triazolonucleoside analogues",

abstract = "A series of novel 2′,3′-diethanethio-2′,3′, 5′-trideoxy-5′-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.",

keywords = "Antitumor, Cancer therapy, Nucleoside, Targeted therapy, Triazole",

author = "Yu, {Jin Lan} and Wu, {Qin Pei} and Zhang, {Qing Shan} and Xi, {Xiao Dong} and Liu, {Ning Ning} and Li, {Yun Zheng} and Liu, {Yan Hong} and Yin, {Hong Quan}",

year = "2010",

month = jul,

doi = "10.1016/j.ejmech.2010.03.038",

language = "English",

volume = "45",

pages = "3219--3222",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "7",

}

TY - JOUR

T1 - Synthesis and antitumor activity of novel 2′,3′-diethanethio- 2′,3′,5′-trideoxy-5′-triazolonucleoside analogues

AU - Yu, Jin Lan

AU - Wu, Qin Pei

AU - Zhang, Qing Shan

AU - Xi, Xiao Dong

AU - Liu, Ning Ning

AU - Li, Yun Zheng

AU - Liu, Yan Hong

AU - Yin, Hong Quan

PY - 2010/7

Y1 - 2010/7

N2 - A series of novel 2′,3′-diethanethio-2′,3′, 5′-trideoxy-5′-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.

AB - A series of novel 2′,3′-diethanethio-2′,3′, 5′-trideoxy-5′-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.

KW - Antitumor

KW - Cancer therapy

KW - Nucleoside

KW - Targeted therapy

KW - Triazole

UR - http://www.scopus.com/inward/record.url?scp=77954348872&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2010.03.038

DO - 10.1016/j.ejmech.2010.03.038

M3 - Article

AN - SCOPUS:77954348872

SN - 0223-5234

VL - 45

SP - 3219

EP - 3222

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 7

ER -

Synthesis and antitumor activity of novel 2′,3′-diethanethio- 2′,3′,5′-trideoxy-5′-triazolonucleoside analogues

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this