Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice

Yaogeng Ma; Min Li; Huilin Sun; Jing Yuan Ge; Yang Bai; Lin Qiu; Xuan Wu; Jiuxi Chen; Zhongyan Chen

doi:10.1039/d3cc04041k

Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice

Yaogeng Ma, Min Li, Huilin Sun, Jing Yuan Ge^*, Yang Bai^*, Lin Qiu, Xuan Wu^*, Jiuxi Chen, Zhongyan Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Two novel near-infrared (NIR) fluorescent probes Cy-Vis1 and Cy-Vis2 with large Stokes shifts (>100 nm) were constructed using a “symmetry collapse” strategy. Notably, Cy-Vis2 was significantly more sensitive to viscosity than Cy-Vis1 through an enhanced intramolecular interaction strategy. The fluorescence intensities of Cy-Vis1 and Cy-Vis2 exhibited increases, by 7.6- and 19.9-fold, respectively, across the viscosity range from 0.8 cp to 359.9 cp. Cy-Vis2 was successfully used to visualize viscosity abnormalities in lipopolysaccharide (LPS)-induced inflammatory and NASH model mice.

Original language	English
Pages (from-to)	14025-14028
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	94
DOIs	https://doi.org/10.1039/d3cc04041k
Publication status	Published - 10 Nov 2023
Externally published	Yes

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title = "Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice",

abstract = "Two novel near-infrared (NIR) fluorescent probes Cy-Vis1 and Cy-Vis2 with large Stokes shifts (>100 nm) were constructed using a “symmetry collapse” strategy. Notably, Cy-Vis2 was significantly more sensitive to viscosity than Cy-Vis1 through an enhanced intramolecular interaction strategy. The fluorescence intensities of Cy-Vis1 and Cy-Vis2 exhibited increases, by 7.6- and 19.9-fold, respectively, across the viscosity range from 0.8 cp to 359.9 cp. Cy-Vis2 was successfully used to visualize viscosity abnormalities in lipopolysaccharide (LPS)-induced inflammatory and NASH model mice.",

author = "Yaogeng Ma and Min Li and Huilin Sun and Ge, {Jing Yuan} and Yang Bai and Lin Qiu and Xuan Wu and Jiuxi Chen and Zhongyan Chen",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = nov,

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doi = "10.1039/d3cc04041k",

language = "English",

volume = "59",

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T1 - Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice

AU - Ma, Yaogeng

AU - Li, Min

AU - Sun, Huilin

AU - Ge, Jing Yuan

AU - Bai, Yang

AU - Qiu, Lin

AU - Wu, Xuan

AU - Chen, Jiuxi

AU - Chen, Zhongyan

PY - 2023/11/10

Y1 - 2023/11/10

N2 - Two novel near-infrared (NIR) fluorescent probes Cy-Vis1 and Cy-Vis2 with large Stokes shifts (>100 nm) were constructed using a “symmetry collapse” strategy. Notably, Cy-Vis2 was significantly more sensitive to viscosity than Cy-Vis1 through an enhanced intramolecular interaction strategy. The fluorescence intensities of Cy-Vis1 and Cy-Vis2 exhibited increases, by 7.6- and 19.9-fold, respectively, across the viscosity range from 0.8 cp to 359.9 cp. Cy-Vis2 was successfully used to visualize viscosity abnormalities in lipopolysaccharide (LPS)-induced inflammatory and NASH model mice.

AB - Two novel near-infrared (NIR) fluorescent probes Cy-Vis1 and Cy-Vis2 with large Stokes shifts (>100 nm) were constructed using a “symmetry collapse” strategy. Notably, Cy-Vis2 was significantly more sensitive to viscosity than Cy-Vis1 through an enhanced intramolecular interaction strategy. The fluorescence intensities of Cy-Vis1 and Cy-Vis2 exhibited increases, by 7.6- and 19.9-fold, respectively, across the viscosity range from 0.8 cp to 359.9 cp. Cy-Vis2 was successfully used to visualize viscosity abnormalities in lipopolysaccharide (LPS)-induced inflammatory and NASH model mice.

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DO - 10.1039/d3cc04041k

M3 - Article

C2 - 37947054

AN - SCOPUS:85176725631

SN - 1359-7345

VL - 59

SP - 14025

EP - 14028

JO - Chemical Communications

JF - Chemical Communications

IS - 94

ER -

Strategic design of an NIR probe for viscosity imaging in inflammatory and non-alcoholic steatohepatitis mice

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