Solid phase extraction of dropropizine using molecularly imprinted polymers

Li Na Geng; Ning Kang; Zhou Yun Ning; Li Qing Wu; Yan Li; Li Quan Sun; Ai Qin Luo

Solid phase extraction of dropropizine using molecularly imprinted polymers

Li Na Geng, Ning Kang, Zhou Yun Ning, Li Qing Wu, Yan Li, Li Quan Sun, Ai Qin Luo^*

^*Corresponding author for this work

School of Life Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Molecularly imprinted polymer (MIP) against dropropizine was synthesized using dropropizine as template, α-methyl acrylic acid as functional monomer, and trimethylolpropane trimethacrylate as crosslinking agent. Its application for separation and enrichment in solid phase extraction was investigated. It was found that, the imprinted polymer exhibited satisfactory performance in recognition and enrichment towards template, but it was not the case with non-imprinted polymer. The retention and separation of imprinted molecule with its structural analogues were also studied. The selectively separation was proved to be successful. The mechanism of imprinted recognition was also discussed here. With the help of PM3 semi-empirical method, the possible MIP system was simulated and compared with experimental results.

Original language	English
Pages (from-to)	25-31
Number of pages	7
Journal	Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica
Volume	24
Issue number	1
Publication status	Published - 2008

Keywords

Dropropizine molecularly imprinted polymer
PM3 computer simulation method
Solid phase extraction separation
Structural analogue

Cite this

@article{8e15ff7368d84079bd297a1e964d161f,

title = "Solid phase extraction of dropropizine using molecularly imprinted polymers",

abstract = "Molecularly imprinted polymer (MIP) against dropropizine was synthesized using dropropizine as template, α-methyl acrylic acid as functional monomer, and trimethylolpropane trimethacrylate as crosslinking agent. Its application for separation and enrichment in solid phase extraction was investigated. It was found that, the imprinted polymer exhibited satisfactory performance in recognition and enrichment towards template, but it was not the case with non-imprinted polymer. The retention and separation of imprinted molecule with its structural analogues were also studied. The selectively separation was proved to be successful. The mechanism of imprinted recognition was also discussed here. With the help of PM3 semi-empirical method, the possible MIP system was simulated and compared with experimental results.",

keywords = "Dropropizine molecularly imprinted polymer, PM3 computer simulation method, Solid phase extraction separation, Structural analogue",

author = "Geng, {Li Na} and Ning Kang and Ning, {Zhou Yun} and Wu, {Li Qing} and Yan Li and Sun, {Li Quan} and Luo, {Ai Qin}",

year = "2008",

language = "English",

volume = "24",

pages = "25--31",

journal = "Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica",

issn = "1000-6818",

publisher = "Chinese Chemical Society and Peking University",

number = "1",

}

TY - JOUR

T1 - Solid phase extraction of dropropizine using molecularly imprinted polymers

AU - Geng, Li Na

AU - Kang, Ning

AU - Ning, Zhou Yun

AU - Wu, Li Qing

AU - Li, Yan

AU - Sun, Li Quan

AU - Luo, Ai Qin

PY - 2008

Y1 - 2008

N2 - Molecularly imprinted polymer (MIP) against dropropizine was synthesized using dropropizine as template, α-methyl acrylic acid as functional monomer, and trimethylolpropane trimethacrylate as crosslinking agent. Its application for separation and enrichment in solid phase extraction was investigated. It was found that, the imprinted polymer exhibited satisfactory performance in recognition and enrichment towards template, but it was not the case with non-imprinted polymer. The retention and separation of imprinted molecule with its structural analogues were also studied. The selectively separation was proved to be successful. The mechanism of imprinted recognition was also discussed here. With the help of PM3 semi-empirical method, the possible MIP system was simulated and compared with experimental results.

AB - Molecularly imprinted polymer (MIP) against dropropizine was synthesized using dropropizine as template, α-methyl acrylic acid as functional monomer, and trimethylolpropane trimethacrylate as crosslinking agent. Its application for separation and enrichment in solid phase extraction was investigated. It was found that, the imprinted polymer exhibited satisfactory performance in recognition and enrichment towards template, but it was not the case with non-imprinted polymer. The retention and separation of imprinted molecule with its structural analogues were also studied. The selectively separation was proved to be successful. The mechanism of imprinted recognition was also discussed here. With the help of PM3 semi-empirical method, the possible MIP system was simulated and compared with experimental results.

KW - Dropropizine molecularly imprinted polymer

KW - PM3 computer simulation method

KW - Solid phase extraction separation

KW - Structural analogue

UR - http://www.scopus.com/inward/record.url?scp=70149106354&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:70149106354

SN - 1000-6818

VL - 24

SP - 25

EP - 31

JO - Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica

JF - Wuli Huaxue Xuebao/ Acta Physico - Chimica Sinica

IS - 1

ER -

Solid phase extraction of dropropizine using molecularly imprinted polymers

Abstract

Keywords

Other files and links

Fingerprint

Cite this