Abstract
Nanozymes with high catalytic stability and sustainability have emerged as powerful competitors to natural enzymes for diverse biocatalytic applications. However, constructing a nanozyme with high specificity is one of their biggest challenges. Herein, we develop a facile solid migration strategy to access a flower-like single copper site nanozyme (Cu SSN) via direct transformation of copper foam activated by 2-methylimidazole. With highly clustered CuN3 sites whose local structure is similar to that of natural polyphenol oxidase, the Cu SSN exhibits excellent activity and specificity to oxidize phenols without peroxidase-like activity. Furthermore, the Cu SSN shows high sensitivity in the colorimetric detection of epinephrine with a low detection limit of 0.10 μg mL−1, exceeding that of most previously reported enzyme-mimicking catalysts. This work not only provides a simple method for the large-scale preparation of high-performance nanozymes but also offers an inspiration for the design of highly specific nanozymes by mimicking the synergy among sites in natural enzymes.
Original language | English |
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Pages (from-to) | 407-415 |
Number of pages | 9 |
Journal | ACS Applied Materials and Interfaces |
Volume | 15 |
Issue number | 1 |
DOIs | |
Publication status | Published - 11 Jan 2023 |
Externally published | Yes |
Keywords
- epinephrine detection
- high specificity
- phenol oxidase-like activity
- single copper sites
- solid migration