TY - JOUR
T1 - Solid-liquid equilibrium, thermodynamic modelling and the solvent effect of glimepiride in mono-solvents and binary mixed solvents
AU - Gao, Xujie
AU - Yu, Shuai
AU - Zhang, Guimin
AU - Cheng, Yan
AU - Wang, Shanshan
AU - Xue, Fumin
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/8/15
Y1 - 2022/8/15
N2 - The solubility of glimepiride (GLM) in eight mono-solvents (including acetonitrile, methyl acetate, acetone, 2-butanone, 1,4-dioxane, cyclohexanone, tetrahydrofuran, and dimethyl sulfoxide) and two binary mixed solvents (N, N-dimethylformamide (DMF) + water, and N, N-Dimethylacetamide (DMA) + water) at 278.15 K to 323.15 K (1,4-dioxane at 288.15 K to 323.15 K; DMSO at 293.15 K to 323.15 K) was determined via the high-performance liquid chromatography (HPLC) method. Solubility increases with the increase of temperature and good-solvent content. The solubility order (T > 293.15 K) of GLM in mono-solvents is DMSO > THF > cyclohexanone > 1,4-dioxane > 2-butanone > acetone > methyl acetate > acetonitrile. The solubility order of GLM in binary mixed solvents is (DMA + water) > (DMF + water) at a given temperature and solvent composition. KAT-LSER model was selected to study the solvent effect of GLM in the tested solvents. In mono-solvents, the experimental solubility data of GLM were correlated by the Yaws model, the modified Apelblat model, the λh model, and the Jouyban model. In binary mixed solvents, the GSM model, the modified Apelblat model, and the Jouyban-Acree-Apelblat model were employed to fit the experimental data. According to RAD and RMSD values, the experimental solubility data of GLM are well corrected. Finally, the thermodynamic properties (i.e., ΔsolHo, ΔsolSo, ΔsolGo, %ζH, and %ζTS) of the dissolution process of GLM were calculated based on the van't Hoff equation.
AB - The solubility of glimepiride (GLM) in eight mono-solvents (including acetonitrile, methyl acetate, acetone, 2-butanone, 1,4-dioxane, cyclohexanone, tetrahydrofuran, and dimethyl sulfoxide) and two binary mixed solvents (N, N-dimethylformamide (DMF) + water, and N, N-Dimethylacetamide (DMA) + water) at 278.15 K to 323.15 K (1,4-dioxane at 288.15 K to 323.15 K; DMSO at 293.15 K to 323.15 K) was determined via the high-performance liquid chromatography (HPLC) method. Solubility increases with the increase of temperature and good-solvent content. The solubility order (T > 293.15 K) of GLM in mono-solvents is DMSO > THF > cyclohexanone > 1,4-dioxane > 2-butanone > acetone > methyl acetate > acetonitrile. The solubility order of GLM in binary mixed solvents is (DMA + water) > (DMF + water) at a given temperature and solvent composition. KAT-LSER model was selected to study the solvent effect of GLM in the tested solvents. In mono-solvents, the experimental solubility data of GLM were correlated by the Yaws model, the modified Apelblat model, the λh model, and the Jouyban model. In binary mixed solvents, the GSM model, the modified Apelblat model, and the Jouyban-Acree-Apelblat model were employed to fit the experimental data. According to RAD and RMSD values, the experimental solubility data of GLM are well corrected. Finally, the thermodynamic properties (i.e., ΔsolHo, ΔsolSo, ΔsolGo, %ζH, and %ζTS) of the dissolution process of GLM were calculated based on the van't Hoff equation.
KW - Glimepiride
KW - KAT-LSER model
KW - Model correlation
KW - Solubility
KW - Thermodynamic properties
UR - http://www.scopus.com/inward/record.url?scp=85133906316&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2022.119402
DO - 10.1016/j.molliq.2022.119402
M3 - Article
AN - SCOPUS:85133906316
SN - 0167-7322
VL - 360
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
M1 - 119402
ER -