Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

Lisheng Lin; Huiyun Lin; Yi Shen; Defu Chen; Ying Gu; Brian C. Wilson; Buhong Li

doi:10.1111/php.13264

Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

Lisheng Lin, Huiyun Lin, Yi Shen, Defu Chen, Ying Gu, Brian C. Wilson, Buhong Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Singlet oxygen (¹O₂) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of ¹O₂ luminescence. The optical imaging system enables direct imaging of ¹O₂ luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on ¹O₂ luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to ¹O₂ luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm² and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative ¹O₂ luminescence and vasoconstriction for V-PDT.

Original language	English
Pages (from-to)	646-651
Number of pages	6
Journal	Photochemistry and Photobiology
Volume	96
Issue number	3
DOIs	https://doi.org/10.1111/php.13264
Publication status	Published - 1 May 2020
Externally published	Yes

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Lin, L., Lin, H., Shen, Y., Chen, D., Gu, Y., Wilson, B. C., & Li, B. (2020). Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy. Photochemistry and Photobiology, 96(3), 646-651. https://doi.org/10.1111/php.13264

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abstract = "Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V-PDT.",

author = "Lisheng Lin and Huiyun Lin and Yi Shen and Defu Chen and Ying Gu and Wilson, {Brian C.} and Buhong Li",

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AU - Lin, Lisheng

AU - Lin, Huiyun

AU - Shen, Yi

AU - Chen, Defu

AU - Gu, Ying

AU - Wilson, Brian C.

AU - Li, Buhong

PY - 2020/5/1

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N2 - Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V-PDT.

AB - Singlet oxygen (1O2) is widely regarded as the main cytotoxic substance that induces the biological damage for photodynamic therapy (PDT). In this study, the previously developed near-infrared (NIR) optical imaging system was optimized for fast imaging of 1O2 luminescence. The optical imaging system enables direct imaging of 1O2 luminescence in blood vessels within 2 s during vascular-targeted PDT (V-PDT), which makes this system extremely practical for in vivo studies. The dependence of RB concentration on 1O2 luminescence image was investigated for V-PDT, and the data imply that 1270 nm signal is attributed to 1O2 luminescence. The imaging system operates with a field of view of 9.60 × 7.68 mm2 and a spatial resolution of 30 μm, which holds the potential to elucidate the correlation between cumulative 1O2 luminescence and vasoconstriction for V-PDT.

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Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy

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