@inproceedings{aaa0c01fec5d40e99e909a2824799105,
title = "Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer",
abstract = "This work aims to apply a fiber-optic Raman spectroscopy technique for in vivo assessment of adenomatous polyps during clinical colonoscopy. We have developed a fiber-optic Raman endoscopic technique capable of simultaneously acquiring both the fingerprint (FP) (i.e., 800-1800 cm-1) and high-wavenumber (HW) (i.e., 2800-3600 cm-1) Raman spectra for real-time assessment of colorectal carcinogenesis. Simultaneous FP/HW Raman endoscopy provides a diagnostic sensitivity of 90.9% and specificity of 83.3% for differentiating adenoma from hyperplastic polyps, which is superior to either the FP or HW Raman technique alone. This study shows that simultaneous FP/HW Raman spectroscopy has the potential for improving early diagnosis of adenomatous polyps in vivo during colonoscopic examination.",
keywords = "Raman spectroscopy, adenomatous polyp, colon, colonoscopy, in vivo optical diagnosis",
author = "Kan Lin and Jianfeng Wang and {Sylvest Bergholt}, Mads and Wei Zheng and Hongzhi Xu and Ren, {Jian Lin} and {Yu Ho}, Khek and Ming Teh and {Guan Yeoh}, Khay and Zhiwei Huang",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II ; Conference date: 07-02-2015 Through 09-02-2015",
year = "2015",
doi = "10.1117/12.2080851",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Suter, {Melissa J.} and Stephen Lam and Matthew Brenner and Tearney, {Guillermo J.} and Wang, {Thomas D.}",
booktitle = "Endoscopic Microscopy X; and Optical Techniques in Pulmonary Medicine II",
address = "United States",
}