Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer

Kan Lin, Wei Zheng, Jianfeng Wang, Chwee Ming Lim, Zhiwei Huang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Raman spectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopic imaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients and differentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ∼85%. This study shows the great potential of the FP/HW Raman endoscopic technique developed for in vivo diagnosis of laryngeal carcinoma during routine endoscopic examination.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics XII
EditorsBernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Melissa C. Skala, Paul J. Campagnola, Andreas Mandelis
PublisherSPIE
ISBN (Electronic)9781628419245
DOIs
Publication statusPublished - 2016
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics XII - San Francisco, United States
Duration: 13 Feb 201614 Feb 2016

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9689
ISSN (Print)1605-7422

Conference

ConferencePhotonic Therapeutics and Diagnostics XII
Country/TerritoryUnited States
CitySan Francisco
Period13/02/1614/02/16

Keywords

  • Raman spectroscopy
  • endoscopy
  • fingerprint
  • high-wavenumber
  • laryngeal cancer

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