Silver-mediated radical trifluoromethylarylation of activated alkenes for the synthesis of oxindoles bearing a CF3 group

Yao Feng Wang; Jiashen Qiu; Dejie Kong; Fu Xue Chen

doi:10.1055/s-0033-1341272

Silver-mediated radical trifluoromethylarylation of activated alkenes for the synthesis of oxindoles bearing a CF₃ group

Yao Feng Wang, Jiashen Qiu, Dejie Kong, Fu Xue Chen^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A radical trifluoromethylarylation of N-arylacrylamides with in situ generated [AgCF₃] species from Me₃SiCF₃ and AgF in DMF is established through a tandem radical addition and C-H activation pathway. It provided a concise method to prepare 21 examples of CF ₃-containing oxindoles within four hours.

Original language	English
Article number	st-2014-w0243-l
Pages (from-to)	1731-1734
Number of pages	4
Journal	Synlett
Volume	25
Issue number	12
DOIs	https://doi.org/10.1055/s-0033-1341272
Publication status	Published - Jul 2014

Keywords

alkenes
radical reactions
silver
tandem reaction
trifluoromethylation
xindole

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abstract = "A radical trifluoromethylarylation of N-arylacrylamides with in situ generated [AgCF3] species from Me3SiCF3 and AgF in DMF is established through a tandem radical addition and C-H activation pathway. It provided a concise method to prepare 21 examples of CF 3-containing oxindoles within four hours.",

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AU - Wang, Yao Feng

AU - Qiu, Jiashen

AU - Kong, Dejie

AU - Chen, Fu Xue

PY - 2014/7

Y1 - 2014/7

N2 - A radical trifluoromethylarylation of N-arylacrylamides with in situ generated [AgCF3] species from Me3SiCF3 and AgF in DMF is established through a tandem radical addition and C-H activation pathway. It provided a concise method to prepare 21 examples of CF 3-containing oxindoles within four hours.

AB - A radical trifluoromethylarylation of N-arylacrylamides with in situ generated [AgCF3] species from Me3SiCF3 and AgF in DMF is established through a tandem radical addition and C-H activation pathway. It provided a concise method to prepare 21 examples of CF 3-containing oxindoles within four hours.

KW - alkenes

KW - radical reactions

KW - silver

KW - tandem reaction

KW - trifluoromethylation

KW - xindole

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DO - 10.1055/s-0033-1341272

M3 - Article

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ER -

Silver-mediated radical trifluoromethylarylation of activated alkenes for the synthesis of oxindoles bearing a CF₃ group

Abstract

Keywords

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