Significance of resveratrol in clinical management of chronic diseases

Awais Wahab; Kuo Gao; Caixia Jia; Feilong Zhang; Guihua Tian; Ghulam Murtaza; Jianxin Chen

doi:10.3390/molecules22081329

Significance of resveratrol in clinical management of chronic diseases

Awais Wahab, Kuo Gao, Caixia Jia, Feilong Zhang, Guihua Tian, Ghulam Murtaza, Jianxin Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

89 Citations (Scopus)

Abstract

Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.

Original language	English
Article number	1329
Journal	Molecules
Volume	22
Issue number	8
DOIs	https://doi.org/10.3390/molecules22081329
Publication status	Published - Aug 2017
Externally published	Yes

Keywords

Absorption
Aging
Cancer
Cardiovascular diseases
Clinical studies
Diabetes mellitus
Obesity
Pre-clinical studies
Toxicity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/molecules22081329

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abstract = "Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.",

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AU - Wahab, Awais

AU - Gao, Kuo

AU - Jia, Caixia

AU - Zhang, Feilong

AU - Tian, Guihua

AU - Murtaza, Ghulam

AU - Chen, Jianxin

PY - 2017/8

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N2 - Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.

AB - Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.

KW - Absorption

KW - Aging

KW - Cancer

KW - Cardiovascular diseases

KW - Clinical studies

KW - Diabetes mellitus

KW - Obesity

KW - Pre-clinical studies

KW - Toxicity

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DO - 10.3390/molecules22081329

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VL - 22

JO - Molecules

JF - Molecules

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ER -

Significance of resveratrol in clinical management of chronic diseases

Abstract

Keywords

UN SDGs

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