Saturated multi-delay renal arterial spin labeling technique for simultaneous perfusion and T₁ quantification in kidneys

Purpose: To propose a free-breathing simultaneous multi-delay arterial spin labeling (ASL) and T₁ mapping technique with a stepwise kinetic model for renal assessment in a single 4-min scan at 3 T. Methods: The proposed saturated multi-delay renal arterial spin labeling (SAMURAI) sequence used flow-sensitive alternating inversion recovery (FAIR) preparation, followed by acquisition of 9 images with Look-Locker spoiled gradient recalled echo (SPGR). Pre-saturation at the imaging slice was used to achieve saturation-based T₁ mapping. A 4-step 2-compartment kinetic model was proposed to characterize water transition through artery- and tissue-compartment. The impact of the Look-Locker sampling scheme on the ASL signal was corrected in this model. T₁ estimation with dictionary searching method and perfusion quantification based on the proposed kinetic model fitting were conducted after groupwise registration of the acquired images. The feasibility and repeatability of SAMURAI were validated in healthy subjects (n = 11) and patients with different renal diseases (n = 4). Results: The proposed SAMURAI technique can provide accurate T₁ map with strong correlation (R² = 0.98) with inversion recovery spin echo (IR-SE) on phantom. SAMURAI provided equally reliable whole kidney and cortical ASL and T₁ quantification results compared with multi-TI FAIR (intraclass correlation coefficient [ICC], 0.880-0.958) and IR-SPGR (ICC, 0.875-0.912), respectively. Low renal blood flow and increased T₁ were detected by SAMURAI in the affected kidneys of the patients. SAMURAI had excellent scan-rescan repeatability (ICC, 0.905-0.992) and significantly reduced scan time (4 min 6 s vs. 45 min for 9 TIs) compared to multi-TI FAIR. Conclusion: The proposed SAMURAI technique is feasible and repeatable for simultaneously quantifying T₁ and perfusion of kidneys with high time-efficiency.