TY - GEN
T1 - Risky decision-making in abstinent heroin addicts
T2 - 9th International Conference on Bioinformatics and Biomedical Technology, ICBBT 2017
AU - Hu, Bin
AU - Zhao, Qinglin
AU - Zhou, Shuangshuang
AU - Peng, Hong
AU - Liu, Quanying
N1 - Publisher Copyright:
© 2017 Association for Computing Machinery.
PY - 2017/5/14
Y1 - 2017/5/14
N2 - Heroin addiction is usually associated with decision-making deficits that they are more likely to accept risk. Understanding the neurocognitive mechanisms underlying risky decision-making in heroin addicts therefore is important not only for interpreting the behavioral or functional impairments for heroin addicts, but also for assessing the treatment outcome in abstinent heroin addicts (AHA). The aim of this study is to investigate the risky decision making in AHA, compared with healthy controls (HC), in terms of their electrophysiological distortions during the performance of gambling tasks. In our study, the gambling task was conducted, involving the high-risk and low-risk choices and then a corresponding positive or negative feedback. During the tasks, 64-channel electroencephalographic (EEG) signals were recorded in 24 AHA subjects and 23 matched HC subjects. The behavioral results showed that AHA preferred to select the high-risk choice, whereas HC did not have this preference. Moreover, the differences of the event related potential (ERP) generated by AHA and HC were examined, particularly the changes in P300 which related to the cognitive and attentional status. Our ERP results showed a significant suppression of P300 intensity in AHA induced by the negative feedback, but not for the positive feedback. This finding implied that the cognitive process during decision-making in AHA might be impaired, with hyposensitivity to punishment.
AB - Heroin addiction is usually associated with decision-making deficits that they are more likely to accept risk. Understanding the neurocognitive mechanisms underlying risky decision-making in heroin addicts therefore is important not only for interpreting the behavioral or functional impairments for heroin addicts, but also for assessing the treatment outcome in abstinent heroin addicts (AHA). The aim of this study is to investigate the risky decision making in AHA, compared with healthy controls (HC), in terms of their electrophysiological distortions during the performance of gambling tasks. In our study, the gambling task was conducted, involving the high-risk and low-risk choices and then a corresponding positive or negative feedback. During the tasks, 64-channel electroencephalographic (EEG) signals were recorded in 24 AHA subjects and 23 matched HC subjects. The behavioral results showed that AHA preferred to select the high-risk choice, whereas HC did not have this preference. Moreover, the differences of the event related potential (ERP) generated by AHA and HC were examined, particularly the changes in P300 which related to the cognitive and attentional status. Our ERP results showed a significant suppression of P300 intensity in AHA induced by the negative feedback, but not for the positive feedback. This finding implied that the cognitive process during decision-making in AHA might be impaired, with hyposensitivity to punishment.
KW - Addiction
KW - Decision making
KW - Event-related potentials
KW - Gamble task
KW - Heroin
UR - http://www.scopus.com/inward/record.url?scp=85025118121&partnerID=8YFLogxK
U2 - 10.1145/3093293.3093302
DO - 10.1145/3093293.3093302
M3 - Conference contribution
AN - SCOPUS:85025118121
T3 - ACM International Conference Proceeding Series
SP - 33
EP - 38
BT - Proceedings of the 2017 9th International Conference on Bioinformatics and Biomedical Technology, ICBBT 2017
PB - Association for Computing Machinery
Y2 - 14 May 2017 through 16 May 2017
ER -