TY - GEN
T1 - Resistive Pulse Study of Liposome Stability
T2 - 2018 IEEE/RSJ International Conference on Intelligent Robots and Systems, IROS 2018
AU - Lin, Yuqing
AU - Liu, Xiaoming
AU - Arai, Tatsuo
N1 - Publisher Copyright:
© 2018 IEEE.
PY - 2018/12/27
Y1 - 2018/12/27
N2 - In this work, the authors report the investigation of liposomes' stability as a drug delivery vehicle, using the method of resistive pulse method. The main objects of interest are the 50nm diameter liposomes, while the 100nm diameter liposomes are widely used for its stability. However, certain drug delivery scenarios arise, like tighter cancerous tissue arrangement and different circulation time requirement, which dictates the necessity of sub-100nm diameter vesicles. The size measurements upon freshly fabricated liposomes are performed frequently on increasing time interval. The results exhibit a trend of size increasing, suggesting the existence of liposome fusion. The possible models of fusion are proposed and discussed. This work demonstrates the localized organic nanoparticle measurement with fine dual 3D manipulator positioning, which paves the way for the possible cellular in-vivo measurement within an environmental SEM chamber.
AB - In this work, the authors report the investigation of liposomes' stability as a drug delivery vehicle, using the method of resistive pulse method. The main objects of interest are the 50nm diameter liposomes, while the 100nm diameter liposomes are widely used for its stability. However, certain drug delivery scenarios arise, like tighter cancerous tissue arrangement and different circulation time requirement, which dictates the necessity of sub-100nm diameter vesicles. The size measurements upon freshly fabricated liposomes are performed frequently on increasing time interval. The results exhibit a trend of size increasing, suggesting the existence of liposome fusion. The possible models of fusion are proposed and discussed. This work demonstrates the localized organic nanoparticle measurement with fine dual 3D manipulator positioning, which paves the way for the possible cellular in-vivo measurement within an environmental SEM chamber.
KW - 3D manipulator
KW - drug delivery vehicle
KW - liposome
KW - resistive pulse method
KW - size measurement
KW - sub 100nm Nano pores
UR - http://www.scopus.com/inward/record.url?scp=85062946648&partnerID=8YFLogxK
U2 - 10.1109/IROS.2018.8593731
DO - 10.1109/IROS.2018.8593731
M3 - Conference contribution
AN - SCOPUS:85062946648
T3 - IEEE International Conference on Intelligent Robots and Systems
SP - 4914
EP - 4919
BT - 2018 IEEE/RSJ International Conference on Intelligent Robots and Systems, IROS 2018
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 1 October 2018 through 5 October 2018
ER -
