Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui; Jian Yang; Qunfang Zhou; Ping Liang; Yaling Wang; Xueyun Gao; Yongtian Wang

doi:10.1021/acsami.6b16133

Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Yanyan Cui^*, Jian Yang, Qunfang Zhou, Ping Liang, Yaling Wang, Xueyun Gao, Yongtian Wang

^*Corresponding author for this work

School of Optics and Photonics

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

Original language	English
Pages (from-to)	5900-5906
Number of pages	7
Journal	ACS applied materials & interfaces
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/acsami.6b16133
Publication status	Published - 22 Feb 2017

Keywords

X-ray CT imaging
photothermal therapy
protein
renal clearable
silver nanodots

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10.1021/acsami.6b16133

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Cui, Y., Yang, J., Zhou, Q., Liang, P., Wang, Y., Gao, X., & Wang, Y. (2017). Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy. ACS applied materials & interfaces, 9(7), 5900-5906. https://doi.org/10.1021/acsami.6b16133

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abstract = "Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.",

keywords = "X-ray CT imaging, photothermal therapy, protein, renal clearable, silver nanodots",

author = "Yanyan Cui and Jian Yang and Qunfang Zhou and Ping Liang and Yaling Wang and Xueyun Gao and Yongtian Wang",

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AU - Zhou, Qunfang

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AU - Wang, Yaling

AU - Gao, Xueyun

AU - Wang, Yongtian

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Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

Abstract

Keywords

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