TY - JOUR
T1 - Recent advances in SERS-based immunochromatographic assay for pathogenic microorganism diagnosis
T2 - A review
AU - Yu, Qing
AU - Wu, Ting
AU - Tian, Benshun
AU - Li, Jiaxuan
AU - Liu, Yun
AU - Wu, Zelan
AU - Jin, Xiong
AU - Wang, Chaoguang
AU - Wang, Chongwen
AU - Gu, Bing
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2024/1/15
Y1 - 2024/1/15
N2 - Infectious diseases caused by bacteria, viruses, fungi, and other pathogenic microorganisms are among the most harmful public health problems in the world, causing tens of millions of deaths and incalculable economic losses every year. The establishment of rapid, simple, and highly sensitive diagnostic methods for pathogenic microorganisms is important for the prevention and control of infectious diseases, guidance of timely treatment, and the reduction of public safety risks. Lateral flow immunoassay (LFA) based on the colorimetric signal of colloidal gold is the most popular point-of-care testing technology at present, but it is limited by poor sensitivity and low throughput and hardly meets the needs of the highly sensitive screening of pathogenic microorganisms. In recent years, the combination of surface-enhanced Raman scattering (SERS) and LFA technology has developed into a novel analytical platform with high sensitivity and multiple detection capabilities and has shown great advantages in the detection of pathogenic microorganisms and infectious diseases. This review summarizes the working principle, design ideas, and application of the existing SERS-based LFA methods in pathogenic microorganism detection and further introduces the effect of new technologies such as Raman signal encoding, magnetic enrichment, novel membrane nanotags, and integrated Raman reading equipment on the performance of SERS-LFA. Finally, the main challenges and the future direction of development in this field of SERS-LFA are discussed.
AB - Infectious diseases caused by bacteria, viruses, fungi, and other pathogenic microorganisms are among the most harmful public health problems in the world, causing tens of millions of deaths and incalculable economic losses every year. The establishment of rapid, simple, and highly sensitive diagnostic methods for pathogenic microorganisms is important for the prevention and control of infectious diseases, guidance of timely treatment, and the reduction of public safety risks. Lateral flow immunoassay (LFA) based on the colorimetric signal of colloidal gold is the most popular point-of-care testing technology at present, but it is limited by poor sensitivity and low throughput and hardly meets the needs of the highly sensitive screening of pathogenic microorganisms. In recent years, the combination of surface-enhanced Raman scattering (SERS) and LFA technology has developed into a novel analytical platform with high sensitivity and multiple detection capabilities and has shown great advantages in the detection of pathogenic microorganisms and infectious diseases. This review summarizes the working principle, design ideas, and application of the existing SERS-based LFA methods in pathogenic microorganism detection and further introduces the effect of new technologies such as Raman signal encoding, magnetic enrichment, novel membrane nanotags, and integrated Raman reading equipment on the performance of SERS-LFA. Finally, the main challenges and the future direction of development in this field of SERS-LFA are discussed.
KW - Lateral flow immunoassay
KW - Pathogenic microorganism
KW - Point-of-care testing
KW - SERS
KW - SERS tags
UR - http://www.scopus.com/inward/record.url?scp=85174859700&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2023.341931
DO - 10.1016/j.aca.2023.341931
M3 - Review article
C2 - 38049231
AN - SCOPUS:85174859700
SN - 0003-2670
VL - 1286
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
M1 - 341931
ER -
