Proteomic analysis of proteins related to Parkinson's disease in the corpus striatum and hippocampus of diabetes rat model

Diabetes is a risk factor for Parkinson's disease (PD). There are statistics data indicating that the prevalence of PD among patients with diabetes was higher compared with the normal people. To date, little is known about the molecular events underlying hyperglycemia-induced PD. Here, the proteins of corpus striatum (ST) and hippocampus from the brains of diabetes rat models and control rats were analyzed by comparing proteomics method. LC-ESI-TOF and LC-ESI-MS/MS were used for analysis. It was found that 23 express levels of proteins, in which including excitatory amino acid transporter, ATP synthase and superoxide dismutase (SOD), were significantly changed in the experiments. It was also found that seven key enzymes which occurred in glycolysis pathway increased significantly in diabetes rat model brains, which mean that the endogenous neurotoxin ADTIQ concentration perhaps had been enhanced. These results indicated that the express levels of several proteins close related to PD which changed under hyperglycemia condition, and it supports the view that diabetes is a risk factor for Parkinson's disease.