Properties study on hydroxypropyl methylcellulose trimellitate

Wen Jun Wang; Zi Qiang Shao; Ya Qing Xu; Yong Hong Li; Li Zhang; Bing Liao

Properties study on hydroxypropyl methylcellulose trimellitate

Wen Jun Wang^*, Zi Qiang Shao, Ya Qing Xu, Yong Hong Li, Li Zhang, Bing Liao

^*Corresponding author for this work

School of Material Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.

Original language	English
Pages (from-to)	270-273
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	29
Issue number	3
Publication status	Published - Mar 2009

Keywords

Enteric-coating
Hydroxypropyl methylcellulose trimellitate
PH sensibility

Cite this

Wang, W. J., Shao, Z. Q., Xu, Y. Q., Li, Y. H., Zhang, L., & Liao, B. (2009). Properties study on hydroxypropyl methylcellulose trimellitate. Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, 29(3), 270-273.

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title = "Properties study on hydroxypropyl methylcellulose trimellitate",

abstract = "Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.",

keywords = "Enteric-coating, Hydroxypropyl methylcellulose trimellitate, PH sensibility",

author = "Wang, {Wen Jun} and Shao, {Zi Qiang} and Xu, {Ya Qing} and Li, {Yong Hong} and Li Zhang and Bing Liao",

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T1 - Properties study on hydroxypropyl methylcellulose trimellitate

AU - Wang, Wen Jun

AU - Shao, Zi Qiang

AU - Xu, Ya Qing

AU - Li, Yong Hong

AU - Zhang, Li

AU - Liao, Bing

PY - 2009/3

Y1 - 2009/3

N2 - Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.

AB - Synthesized a novel kind of enteric-coating material-HPMCT. Its structure and application properties such as dissolving ability in different organic solvent, pH sensibility, coating technical properties and dissolution rate in buffer solution (pH = 6.86) were analyzed by IR and UV. The results indicated that ethanol/methylene chloride, acetone/ethanol/water, acetone/ethanol and ethanol/water were all good solvent systems for the HPMCT; the pH sensibility value range of the HPMCT is 3.8-4.0, the HPMCT can dissolve rapidly in buffer solution (pH = 6.86), achieving tight, smooth and having metallic brightness coating without plasticizer. Dissolution rate of the coated tablet in buffer solution (pH = 6.86) in 20 minutes were 92.60%, which meet the necessity of enteric coating material.

KW - Enteric-coating

KW - Hydroxypropyl methylcellulose trimellitate

KW - PH sensibility

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JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

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ER -

Properties study on hydroxypropyl methylcellulose trimellitate

Abstract

Keywords

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