Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment

Kun Li; Yuquan Zhang; Abid Hussain; Yuhua Weng; Yuanyu Huang

doi:10.1021/acsbiomaterials.1c00765

Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment

Kun Li, Yuquan Zhang, Abid Hussain^*, Yuhua Weng^*, Yuanyu Huang^*

^*Corresponding author for this work

Beijing Institute of Technology

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) is a noninvasive and effective local treatment for cancers that produces selective damage to target tissues and cells. However, PDT alone is unlikely to completely inhibit tumor metastasis and/or local tumor recurrence. RNA interference (RNAi) is a phenomenon of gene silencing mediated by exogenous or endogenous double-stranded RNA (dsRNA). RNAi has entered a golden period of development, with the approval of four treatments employing RNAi. PDT in combination with RNAi therapy to inhibit related targets has been a research hotspot, with better clinical outcomes than monotherapy. In this review, the progress of PDT and small interfering RNA (siRNA) targeting different genes is discussed, while the achievements of the combined immunotherapy are reviewed.

Original language	English
Pages (from-to)	4420-4429
Number of pages	10
Journal	ACS Biomaterials Science and Engineering
Volume	7
Issue number	9
DOIs	https://doi.org/10.1021/acsbiomaterials.1c00765
Publication status	Published - 13 Sept 2021

Keywords

PD-L1
PDT
RNA interference
immunotherapy
photodynamic materials
siRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsbiomaterials.1c00765

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title = "Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment",

abstract = "Photodynamic therapy (PDT) is a noninvasive and effective local treatment for cancers that produces selective damage to target tissues and cells. However, PDT alone is unlikely to completely inhibit tumor metastasis and/or local tumor recurrence. RNA interference (RNAi) is a phenomenon of gene silencing mediated by exogenous or endogenous double-stranded RNA (dsRNA). RNAi has entered a golden period of development, with the approval of four treatments employing RNAi. PDT in combination with RNAi therapy to inhibit related targets has been a research hotspot, with better clinical outcomes than monotherapy. In this review, the progress of PDT and small interfering RNA (siRNA) targeting different genes is discussed, while the achievements of the combined immunotherapy are reviewed.",

keywords = "PD-L1, PDT, RNA interference, immunotherapy, photodynamic materials, siRNA",

author = "Kun Li and Yuquan Zhang and Abid Hussain and Yuhua Weng and Yuanyu Huang",

note = "Publisher Copyright: {\textcopyright} 2021 American Chemical Society",

year = "2021",

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day = "13",

doi = "10.1021/acsbiomaterials.1c00765",

language = "English",

volume = "7",

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T1 - Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment

AU - Li, Kun

AU - Zhang, Yuquan

AU - Hussain, Abid

AU - Weng, Yuhua

AU - Huang, Yuanyu

PY - 2021/9/13

Y1 - 2021/9/13

N2 - Photodynamic therapy (PDT) is a noninvasive and effective local treatment for cancers that produces selective damage to target tissues and cells. However, PDT alone is unlikely to completely inhibit tumor metastasis and/or local tumor recurrence. RNA interference (RNAi) is a phenomenon of gene silencing mediated by exogenous or endogenous double-stranded RNA (dsRNA). RNAi has entered a golden period of development, with the approval of four treatments employing RNAi. PDT in combination with RNAi therapy to inhibit related targets has been a research hotspot, with better clinical outcomes than monotherapy. In this review, the progress of PDT and small interfering RNA (siRNA) targeting different genes is discussed, while the achievements of the combined immunotherapy are reviewed.

AB - Photodynamic therapy (PDT) is a noninvasive and effective local treatment for cancers that produces selective damage to target tissues and cells. However, PDT alone is unlikely to completely inhibit tumor metastasis and/or local tumor recurrence. RNA interference (RNAi) is a phenomenon of gene silencing mediated by exogenous or endogenous double-stranded RNA (dsRNA). RNAi has entered a golden period of development, with the approval of four treatments employing RNAi. PDT in combination with RNAi therapy to inhibit related targets has been a research hotspot, with better clinical outcomes than monotherapy. In this review, the progress of PDT and small interfering RNA (siRNA) targeting different genes is discussed, while the achievements of the combined immunotherapy are reviewed.

KW - PD-L1

KW - PDT

KW - RNA interference

KW - immunotherapy

KW - photodynamic materials

KW - siRNA

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U2 - 10.1021/acsbiomaterials.1c00765

DO - 10.1021/acsbiomaterials.1c00765

M3 - Review article

C2 - 34427082

AN - SCOPUS:85114682253

SN - 2373-9878

VL - 7

SP - 4420

EP - 4429

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 9

ER -

Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment

Abstract

Keywords

UN SDGs

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