Programmable vascular targeted photodynamic therapy device for animal experiment

Wenrui Kang, Xu Wang, Bingshuai Liu, Fanchao Cheng, Xiaoming Hu*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Vascular targeted photodynamic therapy (VPDT) is a new targeted therapy that relies on light as a precise spatially and temporally stimulus. An improved understanding of the interaction between photosensitizers, oxygen and light elements is of great significance to improve the outcomes. A VPDT device for animal evaluation is designed to meet the needs on the regulation of light distribution and irradiance on a same sample. The device is composed of a programmable light source and a micro-camera. The irradiance and spatial distribution can be adjusted by the light-emitting diode current and the duty cycle of the digital micromirror. Experiments show that the optical uniformity of the device is better than 96 percent, the dynamic range is up 28,815 to 1, and the position resolution is 7.6 micron, which can be used for animal experiment.

Original languageEnglish
Title of host publication24th National Laser Conference and Fifteenth National Conference on Laser Technology and Optoelectronics
EditorsJianqiang Zhu, Weibiao Chen, Zhenxi Zhang, Minlin Zhong, Pu Wang, Jianrong Qiu
PublisherSPIE
ISBN (Electronic)9781510642690
DOIs
Publication statusPublished - 2020
Event24th National Laser Conference and 15th National Conference on Laser Technology and Optoelectronics - Shanghai, China
Duration: 17 Oct 202020 Oct 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11717
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference24th National Laser Conference and 15th National Conference on Laser Technology and Optoelectronics
Country/TerritoryChina
CityShanghai
Period17/10/2020/10/20

Keywords

  • Irradiance
  • Optical uniformity
  • Photodynamic therapy

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