Preparation and application of the chiral stationary phase of new CBZ-phenylalanine-β-cyclodextrin bonded silica for high performance liquid chromatography

Li Quan Sun; Guang Hui Ding; Ning Ma; Li Na Geng; Ai Qin Luo

Preparation and application of the chiral stationary phase of new CBZ-phenylalanine-β-cyclodextrin bonded silica for high performance liquid chromatography

Li Quan Sun^*, Guang Hui Ding, Ning Ma, Li Na Geng, Ai Qin Luo

^*Corresponding author for this work

School of Life Science

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

CBZ-phenylalanine was reacted with 6-OH of β-cyclodextrin, then the derivative was bonded to silica to produce a new chiral stationary phase (CSP) for high performance liquid chromatography (HPLC). The derivative of β-cyclodextrin and the CSP were characterized by Molisch color reaction, IR and XPS. Chromatographic performance of the bonded silica CSP was evaluated using benzene and naphthalene as testing materials. The m-, o-, p-isomers of nitrophenol and aminophenol were separated well on the column of the CSP. Enantiomers of clenbuterol hydrochloride and 5, 6-O-isopropyl-3-thio-hexanoic acid-1, 4-lactone were investigated and tolerably separated on the column.

Original language	English
Pages (from-to)	749-752
Number of pages	4
Journal	Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology
Volume	28
Issue number	8
Publication status	Published - Aug 2008

Keywords

Bonded silica
CBZ-phenylalanine-β-cyclodextrin
Chiral stationary phase
High performance liquid chromatography

Cite this

@article{1235760a67344d01bedf16ed5a72999d,

title = "Preparation and application of the chiral stationary phase of new CBZ-phenylalanine-β-cyclodextrin bonded silica for high performance liquid chromatography",

abstract = "CBZ-phenylalanine was reacted with 6-OH of β-cyclodextrin, then the derivative was bonded to silica to produce a new chiral stationary phase (CSP) for high performance liquid chromatography (HPLC). The derivative of β-cyclodextrin and the CSP were characterized by Molisch color reaction, IR and XPS. Chromatographic performance of the bonded silica CSP was evaluated using benzene and naphthalene as testing materials. The m-, o-, p-isomers of nitrophenol and aminophenol were separated well on the column of the CSP. Enantiomers of clenbuterol hydrochloride and 5, 6-O-isopropyl-3-thio-hexanoic acid-1, 4-lactone were investigated and tolerably separated on the column.",

keywords = "Bonded silica, CBZ-phenylalanine-β-cyclodextrin, Chiral stationary phase, High performance liquid chromatography",

author = "Sun, {Li Quan} and Ding, {Guang Hui} and Ning Ma and Geng, {Li Na} and Luo, {Ai Qin}",

year = "2008",

month = aug,

language = "English",

volume = "28",

pages = "749--752",

journal = "Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology",

issn = "1001-0645",

publisher = "Beijing Institute of Technology",

number = "8",

}

Preparation and application of the chiral stationary phase of new CBZ-phenylalanine-β-cyclodextrin bonded silica for high performance liquid chromatography. / Sun, Li Quan; Ding, Guang Hui; Ma, Ning et al.
In: Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology, Vol. 28, No. 8, 08.2008, p. 749-752.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Preparation and application of the chiral stationary phase of new CBZ-phenylalanine-β-cyclodextrin bonded silica for high performance liquid chromatography

AU - Sun, Li Quan

AU - Ding, Guang Hui

AU - Ma, Ning

AU - Geng, Li Na

AU - Luo, Ai Qin

PY - 2008/8

Y1 - 2008/8

N2 - CBZ-phenylalanine was reacted with 6-OH of β-cyclodextrin, then the derivative was bonded to silica to produce a new chiral stationary phase (CSP) for high performance liquid chromatography (HPLC). The derivative of β-cyclodextrin and the CSP were characterized by Molisch color reaction, IR and XPS. Chromatographic performance of the bonded silica CSP was evaluated using benzene and naphthalene as testing materials. The m-, o-, p-isomers of nitrophenol and aminophenol were separated well on the column of the CSP. Enantiomers of clenbuterol hydrochloride and 5, 6-O-isopropyl-3-thio-hexanoic acid-1, 4-lactone were investigated and tolerably separated on the column.

AB - CBZ-phenylalanine was reacted with 6-OH of β-cyclodextrin, then the derivative was bonded to silica to produce a new chiral stationary phase (CSP) for high performance liquid chromatography (HPLC). The derivative of β-cyclodextrin and the CSP were characterized by Molisch color reaction, IR and XPS. Chromatographic performance of the bonded silica CSP was evaluated using benzene and naphthalene as testing materials. The m-, o-, p-isomers of nitrophenol and aminophenol were separated well on the column of the CSP. Enantiomers of clenbuterol hydrochloride and 5, 6-O-isopropyl-3-thio-hexanoic acid-1, 4-lactone were investigated and tolerably separated on the column.

KW - Bonded silica

KW - CBZ-phenylalanine-β-cyclodextrin

KW - Chiral stationary phase

KW - High performance liquid chromatography

UR - http://www.scopus.com/inward/record.url?scp=52349121969&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:52349121969

SN - 1001-0645

VL - 28

SP - 749

EP - 752

JO - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

JF - Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology

IS - 8

ER -

Preparation and application of the chiral stationary phase of new CBZ-phenylalanine-β-cyclodextrin bonded silica for high performance liquid chromatography

Abstract

Keywords

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