Polyoxometalate-Based Metal-Organic Frameworks as the Solid Support to Immobilize MP-11 Enzyme for Enhancing Thermal and Recyclable Stability

Qingqing An; Zhikun Xu; Wenhui Shang; Yongchun Wang; Xingfei Liu; Dongdong Guo; Muling Zeng; Zhiyu Jia

doi:10.1021/acsabm.1c01252

Polyoxometalate-Based Metal-Organic Frameworks as the Solid Support to Immobilize MP-11 Enzyme for Enhancing Thermal and Recyclable Stability

Qingqing An, Zhikun Xu^*, Wenhui Shang, Yongchun Wang, Xingfei Liu, Dongdong Guo, Muling Zeng^*, Zhiyu Jia^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The immobilization of enzymes has received much attention. Metal-organic framework (MOF) as the adsorbent for enzyme encapsulation provides an effective strategy. However, the encapsulation efficacy is not dependent solely on the specific surface area. Though leading into appropriate substrate with negative charge would enhance the encapsulation efficacy. Polyoxometalates (POMs) as the electron sponge would donate electrons without any structural change. In this study, Keggin-type phosphotungstic acid (PW₁₂) was encapsulated in Zirconium metal-organic framework (PW₁₂@UiO-67) as a heterogeneous adsorbent for the encapsulation of enzyme. Our following data proved that this composite cluster could enhance the adsorption of enzyme and the stability of MP-11 was then significantly improved after immobilization.

Original language	English
Pages (from-to)	1222-1229
Number of pages	8
Journal	ACS Applied Bio Materials
Volume	5
Issue number	3
DOIs	https://doi.org/10.1021/acsabm.1c01252
Publication status	Published - 21 Mar 2022

Keywords

enzyme
immobilization
metal-organic frameworks
polyoxometalates
stability

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title = "Polyoxometalate-Based Metal-Organic Frameworks as the Solid Support to Immobilize MP-11 Enzyme for Enhancing Thermal and Recyclable Stability",

abstract = "The immobilization of enzymes has received much attention. Metal-organic framework (MOF) as the adsorbent for enzyme encapsulation provides an effective strategy. However, the encapsulation efficacy is not dependent solely on the specific surface area. Though leading into appropriate substrate with negative charge would enhance the encapsulation efficacy. Polyoxometalates (POMs) as the electron sponge would donate electrons without any structural change. In this study, Keggin-type phosphotungstic acid (PW12) was encapsulated in Zirconium metal-organic framework (PW12@UiO-67) as a heterogeneous adsorbent for the encapsulation of enzyme. Our following data proved that this composite cluster could enhance the adsorption of enzyme and the stability of MP-11 was then significantly improved after immobilization.",

keywords = "enzyme, immobilization, metal-organic frameworks, polyoxometalates, stability",

author = "Qingqing An and Zhikun Xu and Wenhui Shang and Yongchun Wang and Xingfei Liu and Dongdong Guo and Muling Zeng and Zhiyu Jia",

year = "2022",

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doi = "10.1021/acsabm.1c01252",

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T1 - Polyoxometalate-Based Metal-Organic Frameworks as the Solid Support to Immobilize MP-11 Enzyme for Enhancing Thermal and Recyclable Stability

AU - An, Qingqing

AU - Xu, Zhikun

AU - Shang, Wenhui

AU - Wang, Yongchun

AU - Liu, Xingfei

AU - Guo, Dongdong

AU - Zeng, Muling

AU - Jia, Zhiyu

PY - 2022/3/21

Y1 - 2022/3/21

N2 - The immobilization of enzymes has received much attention. Metal-organic framework (MOF) as the adsorbent for enzyme encapsulation provides an effective strategy. However, the encapsulation efficacy is not dependent solely on the specific surface area. Though leading into appropriate substrate with negative charge would enhance the encapsulation efficacy. Polyoxometalates (POMs) as the electron sponge would donate electrons without any structural change. In this study, Keggin-type phosphotungstic acid (PW12) was encapsulated in Zirconium metal-organic framework (PW12@UiO-67) as a heterogeneous adsorbent for the encapsulation of enzyme. Our following data proved that this composite cluster could enhance the adsorption of enzyme and the stability of MP-11 was then significantly improved after immobilization.

AB - The immobilization of enzymes has received much attention. Metal-organic framework (MOF) as the adsorbent for enzyme encapsulation provides an effective strategy. However, the encapsulation efficacy is not dependent solely on the specific surface area. Though leading into appropriate substrate with negative charge would enhance the encapsulation efficacy. Polyoxometalates (POMs) as the electron sponge would donate electrons without any structural change. In this study, Keggin-type phosphotungstic acid (PW12) was encapsulated in Zirconium metal-organic framework (PW12@UiO-67) as a heterogeneous adsorbent for the encapsulation of enzyme. Our following data proved that this composite cluster could enhance the adsorption of enzyme and the stability of MP-11 was then significantly improved after immobilization.

KW - enzyme

KW - immobilization

KW - metal-organic frameworks

KW - polyoxometalates

KW - stability

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U2 - 10.1021/acsabm.1c01252

DO - 10.1021/acsabm.1c01252

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SN - 2576-6422

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IS - 3

ER -

Polyoxometalate-Based Metal-Organic Frameworks as the Solid Support to Immobilize MP-11 Enzyme for Enhancing Thermal and Recyclable Stability

Abstract

Keywords

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