Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening

Heng Zhang; Xiao Jin; Hanwen Zhao; Yongping Lin; Xiaofeng Li; Lianping Hou; John Marsh; Lei Dong; Daming Shi; Weiping Liu; Bin Xu; Bin Ni; Juan Liu; Jichuan Xiong; Xuefeng Liu

doi:10.1109/JPHOT.2021.3074386

Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening

Heng Zhang, Xiao Jin, Hanwen Zhao, Yongping Lin, Xiaofeng Li, Lianping Hou, John Marsh, Lei Dong, Daming Shi, Weiping Liu, Bin Xu, Bin Ni, Juan Liu^*, Jichuan Xiong^*, Xuefeng Liu^*

^*Corresponding author for this work

School of Life Science

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.

Original language	English
Article number	9409619
Journal	IEEE Photonics Journal
Volume	13
Issue number	3
DOIs	https://doi.org/10.1109/JPHOT.2021.3074386
Publication status	Published - Jun 2021

Keywords

Polarization state
gold nanoparticles
signal amplification
virus

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10.1109/JPHOT.2021.3074386

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title = "Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening",

abstract = "The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.",

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author = "Heng Zhang and Xiao Jin and Hanwen Zhao and Yongping Lin and Xiaofeng Li and Lianping Hou and John Marsh and Lei Dong and Daming Shi and Weiping Liu and Bin Xu and Bin Ni and Juan Liu and Jichuan Xiong and Xuefeng Liu",

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doi = "10.1109/JPHOT.2021.3074386",

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AU - Zhang, Heng

AU - Jin, Xiao

AU - Zhao, Hanwen

AU - Lin, Yongping

AU - Li, Xiaofeng

AU - Hou, Lianping

AU - Marsh, John

AU - Dong, Lei

AU - Shi, Daming

AU - Liu, Weiping

AU - Xu, Bin

AU - Ni, Bin

AU - Liu, Juan

AU - Xiong, Jichuan

AU - Liu, Xuefeng

PY - 2021/6

Y1 - 2021/6

N2 - The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.

AB - The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.

KW - Polarization state

KW - gold nanoparticles

KW - signal amplification

KW - virus

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JO - IEEE Photonics Journal

JF - IEEE Photonics Journal

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ER -

Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening

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Keywords

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