Zhang, H., Jin, X., Zhao, H., Lin, Y., Li, X., Hou, L., Marsh, J., Dong, L., Shi, D., Liu, W., Xu, B., Ni, B., Liu, J., Xiong, J., & Liu, X. (2021). Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening. IEEE Photonics Journal, 13(3), Article 9409619. https://doi.org/10.1109/JPHOT.2021.3074386
Zhang, Heng ; Jin, Xiao ; Zhao, Hanwen et al. / Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening. In: IEEE Photonics Journal. 2021 ; Vol. 13, No. 3.
@article{07a417e58bca4be79c42c3b5370e0ee8,
title = "Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening",
abstract = "The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.",
keywords = "Polarization state, gold nanoparticles, signal amplification, virus",
author = "Heng Zhang and Xiao Jin and Hanwen Zhao and Yongping Lin and Xiaofeng Li and Lianping Hou and John Marsh and Lei Dong and Daming Shi and Weiping Liu and Bin Xu and Bin Ni and Juan Liu and Jichuan Xiong and Xuefeng Liu",
note = "Publisher Copyright: {\textcopyright} 2009-2012 IEEE.",
year = "2021",
month = jun,
doi = "10.1109/JPHOT.2021.3074386",
language = "English",
volume = "13",
journal = "IEEE Photonics Journal",
issn = "1943-0655",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "3",
}
Zhang, H, Jin, X, Zhao, H, Lin, Y, Li, X, Hou, L, Marsh, J, Dong, L, Shi, D, Liu, W, Xu, B, Ni, B, Liu, J, Xiong, J & Liu, X 2021, 'Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening', IEEE Photonics Journal, vol. 13, no. 3, 9409619. https://doi.org/10.1109/JPHOT.2021.3074386
Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening. / Zhang, Heng; Jin, Xiao; Zhao, Hanwen et al.
In:
IEEE Photonics Journal, Vol. 13, No. 3, 9409619, 06.2021.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening
AU - Zhang, Heng
AU - Jin, Xiao
AU - Zhao, Hanwen
AU - Lin, Yongping
AU - Li, Xiaofeng
AU - Hou, Lianping
AU - Marsh, John
AU - Dong, Lei
AU - Shi, Daming
AU - Liu, Weiping
AU - Xu, Bin
AU - Ni, Bin
AU - Liu, Juan
AU - Xiong, Jichuan
AU - Liu, Xuefeng
N1 - Publisher Copyright:
© 2009-2012 IEEE.
PY - 2021/6
Y1 - 2021/6
N2 - The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.
AB - The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which limits the imaging sensitivity for viral particles which have little refractivity contrast with their nano-ambientes. In this paper, we show the photon scattering signal strength can be magnified by introducing a more abrupt change of refractivity at the virus particle using antibody-conjugated gold nanoparticles (AuNPs), allowing the presence of such viruses to be detected. Using two different deep learning methods to minimize scattering noise, the photon states scattering signal of a AuNPs ligated virus is enhanced significantly compared to that of a bare virus particle. This is confirmed by Finite Difference Time Domain (FDTD) numerical simulations. The sensitivity of the polarization state scattering spectra from a virus-gold particle doublet is 5.4 times higher than that of a conventional microscope image.
KW - Polarization state
KW - gold nanoparticles
KW - signal amplification
KW - virus
UR - http://www.scopus.com/inward/record.url?scp=85104642442&partnerID=8YFLogxK
U2 - 10.1109/JPHOT.2021.3074386
DO - 10.1109/JPHOT.2021.3074386
M3 - Article
AN - SCOPUS:85104642442
SN - 1943-0655
VL - 13
JO - IEEE Photonics Journal
JF - IEEE Photonics Journal
IS - 3
M1 - 9409619
ER -
Zhang H, Jin X, Zhao H, Lin Y, Li X, Hou L et al. Photo Scattering Signal Amplification in Gold-Viral Particle Ligation towards Fast Infection Screening. IEEE Photonics Journal. 2021 Jun;13(3):9409619. doi: 10.1109/JPHOT.2021.3074386
