Palladium-Catalyzed Decarboxylative Synthesis of Arylamines

Qipu Dai; Peihe Li; Nuannuan Ma; Changwen Hu

doi:10.1021/acs.orglett.6b02724

Palladium-Catalyzed Decarboxylative Synthesis of Arylamines

Qipu Dai^*, Peihe Li, Nuannuan Ma, Changwen Hu

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Beijing Institute of Technology

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp²)-N bond under mild conditions.

Original language	English
Pages (from-to)	5560-5563
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	21
DOIs	https://doi.org/10.1021/acs.orglett.6b02724
Publication status	Published - 4 Nov 2016

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Dai, Q., Li, P., Ma, N., & Hu, C. (2016). Palladium-Catalyzed Decarboxylative Synthesis of Arylamines. Organic Letters, 18(21), 5560-5563. https://doi.org/10.1021/acs.orglett.6b02724

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title = "Palladium-Catalyzed Decarboxylative Synthesis of Arylamines",

abstract = "A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions.",

author = "Qipu Dai and Peihe Li and Nuannuan Ma and Changwen Hu",

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AU - Dai, Qipu

AU - Li, Peihe

AU - Ma, Nuannuan

AU - Hu, Changwen

PY - 2016/11/4

Y1 - 2016/11/4

N2 - A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions.

AB - A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions.

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Palladium-Catalyzed Decarboxylative Synthesis of Arylamines

Abstract

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