Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora

Jing Fang Zhang; Yan Cheng Li; Yun Qing Song; Gui Yang Xia; Huan Xia; Ya Nan Wang; Gui Hua Tian; Guang Bo Ge; Sheng Lin

doi:10.1016/j.bioorg.2021.104783

Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora

Jing Fang Zhang, Yan Cheng Li, Yun Qing Song, Gui Yang Xia, Huan Xia, Ya Nan Wang, Gui Hua Tian^*, Guang Bo Ge, Sheng Lin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Paeonone A (1), a unique nonanortriterpenoid, and a new octanortriterpenoid, paeonone B (2), were isolated from the roots of Paeonia lactiflora, together with a known analogue, palbinone (3). Paeonone A (1) is the first example of naturally occurring nonanortriterpenoid with a diketo acid group. Extensive NMR and HRESIMS experiments were applied to identify the structures of 1 and 2, and their absolute configurations were solved by single-crystal X-ray diffraction and ECD data. Biological properties of 1–3 were explored against pancreatic lipase and cancer cell lines.

Original language	English
Article number	104783
Journal	Bioorganic Chemistry
Volume	110
DOIs	https://doi.org/10.1016/j.bioorg.2021.104783
Publication status	Published - May 2021
Externally published	Yes

Keywords

Nonanortriterpenoid
Paeonia lactiflora
Paeonone A
Pancreatic lipase inhibition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bioorg.2021.104783

Cite this

@article{5dbd20f11cda4d399d94921168016b4b,

title = "Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora",

abstract = "Paeonone A (1), a unique nonanortriterpenoid, and a new octanortriterpenoid, paeonone B (2), were isolated from the roots of Paeonia lactiflora, together with a known analogue, palbinone (3). Paeonone A (1) is the first example of naturally occurring nonanortriterpenoid with a diketo acid group. Extensive NMR and HRESIMS experiments were applied to identify the structures of 1 and 2, and their absolute configurations were solved by single-crystal X-ray diffraction and ECD data. Biological properties of 1–3 were explored against pancreatic lipase and cancer cell lines.",

keywords = "Nonanortriterpenoid, Paeonia lactiflora, Paeonone A, Pancreatic lipase inhibition",

author = "Zhang, {Jing Fang} and Li, {Yan Cheng} and Song, {Yun Qing} and Xia, {Gui Yang} and Huan Xia and Wang, {Ya Nan} and Tian, {Gui Hua} and Ge, {Guang Bo} and Sheng Lin",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = may,

doi = "10.1016/j.bioorg.2021.104783",

language = "English",

volume = "110",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora

AU - Zhang, Jing Fang

AU - Li, Yan Cheng

AU - Song, Yun Qing

AU - Xia, Gui Yang

AU - Xia, Huan

AU - Wang, Ya Nan

AU - Tian, Gui Hua

AU - Ge, Guang Bo

AU - Lin, Sheng

PY - 2021/5

Y1 - 2021/5

N2 - Paeonone A (1), a unique nonanortriterpenoid, and a new octanortriterpenoid, paeonone B (2), were isolated from the roots of Paeonia lactiflora, together with a known analogue, palbinone (3). Paeonone A (1) is the first example of naturally occurring nonanortriterpenoid with a diketo acid group. Extensive NMR and HRESIMS experiments were applied to identify the structures of 1 and 2, and their absolute configurations were solved by single-crystal X-ray diffraction and ECD data. Biological properties of 1–3 were explored against pancreatic lipase and cancer cell lines.

AB - Paeonone A (1), a unique nonanortriterpenoid, and a new octanortriterpenoid, paeonone B (2), were isolated from the roots of Paeonia lactiflora, together with a known analogue, palbinone (3). Paeonone A (1) is the first example of naturally occurring nonanortriterpenoid with a diketo acid group. Extensive NMR and HRESIMS experiments were applied to identify the structures of 1 and 2, and their absolute configurations were solved by single-crystal X-ray diffraction and ECD data. Biological properties of 1–3 were explored against pancreatic lipase and cancer cell lines.

KW - Nonanortriterpenoid

KW - Paeonia lactiflora

KW - Paeonone A

KW - Pancreatic lipase inhibition

UR - http://www.scopus.com/inward/record.url?scp=85105766098&partnerID=8YFLogxK

U2 - 10.1016/j.bioorg.2021.104783

DO - 10.1016/j.bioorg.2021.104783

M3 - Article

C2 - 33714021

AN - SCOPUS:85105766098

SN - 0045-2068

VL - 110

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 104783

ER -

Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this